Document Detail


Coexisting thymic and gastric lymphomas of mucosa-associated lymphoid tissues in a patient with Sjögren syndrome.
MedLine Citation:
PMID:  10782167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lymphomas of mucosa-associated lymphoid tissues (MALTomas) arising from the thymus are extremely rare. In this case report, we describe a 36-year-old woman with an 11-year history of Sjögren syndrome who was found to have a thymic MALToma coexisting with a gastric MALToma. Both tumors shared similar histologic features, showing clusters of centrocytic-like B cells, lymphoepithelial lesions, and prominent plasmacytic differentiation. They also showed the following identical immunohistochemical features: CD20(+), IgA/lambda(+), CD5(-), and CD43(-). Molecular studies using polymerase chain reaction methods revealed monoclonal gene rearrangement of the immunoglobulin heavy chain in the gastric MALToma, but not in the thymic MALToma. The possible pathogenesis of this unusual case is discussed.
Authors:
T Nagasaka; R Lai; T Harada; Y Y Chen; W G Chen; D A Arber; L M Weiss
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  124     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-26     Completed Date:  2000-06-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  770-3     Citation Subset:  AIM; IM    
Affiliation:
Division of Pathology, Nagoya University Hospital, Nagoya, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Fatal Outcome
Female
Humans
Immunohistochemistry
Lymphoma, B-Cell, Marginal Zone / complications,  metabolism,  pathology*,  radiography,  surgery
Neoplasm Recurrence, Local
Neoplasms, Multiple Primary / complications,  metabolism,  pathology*,  radiography,  surgery
Sjogren's Syndrome / complications*
Stomach Neoplasms / complications,  metabolism,  pathology*,  radiography,  surgery
Thymus Neoplasms / complications,  metabolism,  pathology*,  radiography,  surgery
Tomography, X-Ray Computed
Tumor Markers, Biological / metabolism
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological

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