| Coexisting thymic and gastric lymphomas of mucosa-associated lymphoid tissues in a patient with Sjögren syndrome. | |
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MedLine Citation:
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PMID: 10782167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphomas of mucosa-associated lymphoid tissues (MALTomas) arising from the thymus are extremely rare. In this case report, we describe a 36-year-old woman with an 11-year history of Sjögren syndrome who was found to have a thymic MALToma coexisting with a gastric MALToma. Both tumors shared similar histologic features, showing clusters of centrocytic-like B cells, lymphoepithelial lesions, and prominent plasmacytic differentiation. They also showed the following identical immunohistochemical features: CD20(+), IgA/lambda(+), CD5(-), and CD43(-). Molecular studies using polymerase chain reaction methods revealed monoclonal gene rearrangement of the immunoglobulin heavy chain in the gastric MALToma, but not in the thymic MALToma. The possible pathogenesis of this unusual case is discussed. |
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Authors:
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T Nagasaka; R Lai; T Harada; Y Y Chen; W G Chen; D A Arber; L M Weiss |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 124 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-06-26 Completed Date: 2000-06-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 770-3 Citation Subset: AIM; IM |
Affiliation:
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Division of Pathology, Nagoya University Hospital, Nagoya, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Fatal Outcome Female Humans Immunohistochemistry Lymphoma, B-Cell, Marginal Zone / complications, metabolism, pathology*, radiography, surgery Neoplasm Recurrence, Local Neoplasms, Multiple Primary / complications, metabolism, pathology*, radiography, surgery Sjogren's Syndrome / complications* Stomach Neoplasms / complications, metabolism, pathology*, radiography, surgery Thymus Neoplasms / complications, metabolism, pathology*, radiography, surgery Tomography, X-Ray Computed Tumor Markers, Biological / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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