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Coexisting seizures in patients with infantile spasms confirmed by long-term video-electroencephalography monitoring.
MedLine Citation:
PMID:  22459640     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: We performed this study to evaluate the frequency, types, and ictal electroencephalography (EEG) findings of coexisting seizures in patients with infantile spasms at the onset of spasms. We also evaluated the effect of coexisting seizures on short-term seizure control. METHODS: We retrospectively reviewed the long-term video-EEG and electronic medical records of 109 patients (58 boys and 51 girls) diagnosed with infantile spasms at the Seoul National University Children's Hospital. Coexisting seizure types were classified according to the International League Against Epilepsy seizure and epilepsy classification. Ictal EEG findings were also reviewed. Short-term seizure control rates were compared between groups with or without coexisting seizures. RESULTS: We identified 27 coexisting seizures in 24 of the 109 patients (22%). The most common type of seizure was generalized tonic seizure followed by myoclonic, focal tonic, tonic-clonic, hypokinetic, and versive seizures. Rates of preterm birth and birth asphyxia were significantly higher in patients with coexisting seizures. Initial anticonvulsant was vigabatrin (103 patients), valproic acid (five patients), and topiramate (one patient). There was no significant difference in short-term seizure freedom (overall seizure-free rates in patients without coexisting seizures vs. those with: 29.2% vs. 11.1% at 2months, 36.1% vs. 22.2% at 4months, and 41.7% vs. 27.8% at 6months). Seizure freedom was significantly lower in the symptomatic groups compared with non-symptomatic groups. CONCLUSIONS: Long-term video-EEG monitoring is required as an initial evaluation in patients with infantile spasms, especially when there are reports of coexisting seizures, or a history of preterm birth or birth asphyxia. Presence of coexisting seizures was not related to poor seizure control in the short-term treatment period.
Authors:
Hunmin Kim; Jeong Ho Lee; Hye Won Ryu; Jong-Hee Chae; Jieun Choi; Ki Joong Kim; Yong Seung Hwang; Hee Hwang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-27
Journal Detail:
Title:  Epilepsy research     Volume:  -     ISSN:  1872-6844     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Department of Pediatrics, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
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