Document Detail

Coexisting macrophage-associated fibrin formation and tumor cell urokinase in squamous cell and adenocarcinoma of the lung tissues.
MedLine Citation:
PMID:  1913476     Owner:  NLM     Status:  MEDLINE    
Mechanisms of coagulation activation in situ were studied by means of immunohistochemical techniques applied to surgically resected primary adenocarcinomas and squamous cell carcinomas of the lung. Findings in these two histologic types were similar. Double-labeling techniques using macrophage-specific antibody together with antibody to either tissue factor, factor VII, factor X, or factor V revealed coincident staining for each of these coagulation factors on tumor-associated macrophages. Staining of tumor cells for these factors was rare and inconsistent. Both macrophages and fibroblasts in the tumor connective tissue stained for the a subunit of factor XIII. Fibrinogen was abundant throughout the tumor connective tissue, but staining for fibrin and D-dimer cross-linked sites of fibrin was restricted to areas adjacent to macrophages, indicating that thrombin was generated in association with tumor macrophages but not with tumor cells. By contrast, tumor cells stained diffusely for urokinase-type plasminogen activator and focally for thrombomodulin. These findings contrast with those reported previously for small cell carcinoma of the lung and suggest that coagulation activation in adenocarcinoma and squamous cell carcinoma of the lung may occur indirectly through activation of certain host cells such as macrophages. By contrast, tumor cell plasminogen activator may mediate certain aspects of the malignant phenotype in these tumor types.
D L Ornstein; L R Zacharski; V A Memoli; W Kisiel; B J Kudryk; J Hunt; S M Rousseau; D C Stump
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  68     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-11-12     Completed Date:  1991-11-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1061-7     Citation Subset:  AIM; IM    
Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire.
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MeSH Terms
Adenocarcinoma / blood*,  enzymology,  metabolism
Antibody Specificity
Antigens, Neoplasm / analysis
Blood Coagulation / physiology
Carcinoma, Squamous Cell / blood*,  enzymology,  metabolism
Fibrin / biosynthesis*,  physiology
Fibrinolysis / physiology
Lung Neoplasms / blood*,  enzymology,  metabolism
Macrophages / immunology,  metabolism*,  physiology
Thrombin / biosynthesis
Urokinase-Type Plasminogen Activator / blood*
Grant Support
Reg. No./Substance:
0/Antigens, Neoplasm; 9001-31-4/Fibrin; EC; EC Plasminogen Activator

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