Document Detail

Coexistent primary open-angle glaucoma and cataract: preliminary analysis of treatment by cataract surgery and the iStent trabecular micro-bypass stent.
MedLine Citation:
PMID:  18594784     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Reducing intraocular pressure (IOP) is the only proven treatment modality for reducing the risk of glaucomatous progression. In this study, we evaluated the safety and efficacy of a new tool in IOP reduction, implanted with cataract surgery: the Glaukos iStent trabecular micro-bypass stent. METHODS: This was a prospective, 24-month, uncontrolled, non-randomised, multicentre study. Subjects with uncontrolled primary open-angle glaucoma (including pseudoexfoliation and pigmentary) and a cataract underwent clear cornea phacoemulsification cataract extraction with ab-interno gonioscopically guided implantation of the study stent. Subjects who had completed at least 6 months of follow-up were included in this interim analysis (n=47). RESULTS: At baseline, mean (+/-standard deviation) IOP was 21.5+/-3.7 mmHg, and subjects were taking a mean of 1.5+/-0.7 ocular hypotensive medications. Six months after implantation of the study stent the mean IOP was 15.8+/- 3.0 mmHg, a mean IOP reduction of 5.7+/-3.8 mmHg (25.4%, P<0.001). The mean number of patient medications after 6 months was 0.5+/-0.8 medications, a mean decrease of 1.0+/-0.8 medications (66.7%, P<0.001). Most subjects (70%) were able to discontinue all glaucoma medications. There were no complications traditionally associated with filtering surgery, and no serious adverse events were reported. CONCLUSION: In this interim analysis of subjects with glaucoma and cataracts, this novel stent implantation in subjects undergoing cataract surgery represents a new surgical approach to provide clinically significant decreases in IOP and drug burden.
Detlev Spiegel; Julian García-Feijoó; Julián García-Sánchez; Helene Lamielle
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Advances in therapy     Volume:  25     ISSN:  0741-238X     ISO Abbreviation:  Adv Ther     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-07-02     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8611864     Medline TA:  Adv Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  453-64     Citation Subset:  T    
Klinik Vincetinum, Augsberg, Germany.
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MeSH Terms
Cataract / complications*
Glaucoma, Open-Angle / complications*,  physiopathology,  surgery
Intraocular Pressure
Lens Implantation, Intraocular
Trabeculectomy / instrumentation*,  methods

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