| Coexistent primary open-angle glaucoma and cataract: preliminary analysis of treatment by cataract surgery and the iStent trabecular micro-bypass stent. | |
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MedLine Citation:
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PMID: 18594784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Reducing intraocular pressure (IOP) is the only proven treatment modality for reducing the risk of glaucomatous progression. In this study, we evaluated the safety and efficacy of a new tool in IOP reduction, implanted with cataract surgery: the Glaukos iStent trabecular micro-bypass stent. METHODS: This was a prospective, 24-month, uncontrolled, non-randomised, multicentre study. Subjects with uncontrolled primary open-angle glaucoma (including pseudoexfoliation and pigmentary) and a cataract underwent clear cornea phacoemulsification cataract extraction with ab-interno gonioscopically guided implantation of the study stent. Subjects who had completed at least 6 months of follow-up were included in this interim analysis (n=47). RESULTS: At baseline, mean (+/-standard deviation) IOP was 21.5+/-3.7 mmHg, and subjects were taking a mean of 1.5+/-0.7 ocular hypotensive medications. Six months after implantation of the study stent the mean IOP was 15.8+/- 3.0 mmHg, a mean IOP reduction of 5.7+/-3.8 mmHg (25.4%, P<0.001). The mean number of patient medications after 6 months was 0.5+/-0.8 medications, a mean decrease of 1.0+/-0.8 medications (66.7%, P<0.001). Most subjects (70%) were able to discontinue all glaucoma medications. There were no complications traditionally associated with filtering surgery, and no serious adverse events were reported. CONCLUSION: In this interim analysis of subjects with glaucoma and cataracts, this novel stent implantation in subjects undergoing cataract surgery represents a new surgical approach to provide clinically significant decreases in IOP and drug burden. |
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Authors:
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Detlev Spiegel; Julian García-Feijoó; Julián García-Sánchez; Helene Lamielle |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Advances in therapy Volume: 25 ISSN: 0741-238X ISO Abbreviation: Adv Ther Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-07-02 Completed Date: 2009-01-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8611864 Medline TA: Adv Ther Country: United States |
Other Details:
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Languages: eng Pagination: 453-64 Citation Subset: T |
Affiliation:
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Klinik Vincetinum, Augsberg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cataract / complications* Female Glaucoma, Open-Angle / complications*, physiopathology, surgery Humans Intraocular Pressure Lens Implantation, Intraocular Male Phacoemulsification* Stents* Trabeculectomy / instrumentation*, methods |
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