Document Detail

Coexistent myelodysplasia and plasma cell neoplasia.
MedLine Citation:
PMID:  6849839     Owner:  NLM     Status:  MEDLINE    
The oncogenic effect of alkylating agents, particularly that of melphalan, has been postulated as the most likely cause of myelodysplastic syndrome (MDS) and acute leukaemia in patients with plasma cell neoplasia. Five patients aged between 69 and 79 years were found to have features of MDS at the time of diagnosis of multiple myeloma. In three of these cases MDS transformed into acute leukaemia. These patients had not received any chemotherapy prior to their presentation. The possible importance of these features is discussed.
G J Mufti; T J Hamblin; G P Clein; C Race
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  54     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  91-6     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Bone Marrow Diseases / complications*
Leukemia / etiology
Multiple Myeloma / complications*

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