Document Detail


Coexistent familial nonmultiple endocrine neoplasia medullary thyroid carcinoma and papillary thyroid carcinoma associated with RET polymorphism.
MedLine Citation:
PMID:  20463576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Familial nonmultiple endocrine neoplasia medullary thyroid cancer accounts for 10% to 15% of hereditary medullary thyroid carcinoma and is characterized by lack of accompanying endocrine or nonendocrine diseases. Simultaneous occurrence of medullary and papillary thyroid carcinoma in the same patient is rare and known as collision tumor. Here, the authors present familial nonmultiple endocrine neoplasia medullary thyroid cancer in 4 sisters, all having RET proto-oncogene polymorphism in exon 15 at codon 904 and 2 having additional polymorphism in exon 13 at codon 769. The index case had concomitant medullary and papillary thyroid carcinomas, which are suggested to be completely different tumors in terms of incidence, cell origin, histopathologic features and prognosis. Histopathologically, she also had Hashimoto thyroiditis in the remaining thyroid tissue and medullary thyroid carcinoma metastasis in 3 cervical lymph nodes. This case is the first in the literature to report coexistent familial nonmultiple endocrine neoplasia medullary thyroid cancer and papillary thyroid carcinoma related with a RET polymorphism (S904S in exon 15).
Authors:
Kamile Gul; Didem Ozdemir; Serdar Ugras; Serap S Inancli; Reyhan Ersoy; Bekir Cakir
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  340     ISSN:  1538-2990     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-08-05     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  60-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Endocrinology and Metabolism, Ankara Ataturk Education and Research Hospital, Bilkent, Ankara, Turkey. kamilegul@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Carcinoma, Medullary / diagnosis,  genetics*
Carcinoma, Papillary / diagnosis,  genetics*
Female
Genetic Predisposition to Disease
Hashimoto Disease / complications,  diagnosis
Humans
Middle Aged
Neoplasms, Multiple Primary / diagnosis,  genetics*
Polymorphism, Genetic
Proto-Oncogene Proteins c-ret / genetics*
Thyroid Neoplasms / diagnosis,  genetics*
Chemical
Reg. No./Substance:
EC 2.7.10.1/Proto-Oncogene Proteins c-ret; EC 2.7.10.1/RET protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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