Document Detail

Coexistence of xeroderma pigmentosum with sarcoidosis and adenocarcinoma of the digestive organs.
MedLine Citation:
PMID:  11200839     Owner:  NLM     Status:  MEDLINE    
Xeroderma pigmentosum has not been reported in association with any specific diseases except for skin malignancy. We observed a case of its coexistence with sarcoidosis and adenocarcinoma of the digestive organs, which has been reported only once in the past. A 54-year-old Japanese female with a variant type of xeroderma pigmentosum developed successively multiple lesions of basal cell carcinoma and squamous cell carcinoma on her face. Intensive metastasis studies led to the incidental detection of non-caseating epithelioid cell granulomas in one of the palpable right supraclavicular lymph nodes. Similar granulomas were also revealed in the excised tissue specimen of squamous cell carcinomas of her left cheek. She was also found to have bilateral hilar lymphadenopathy and chronic uveitis. Three years later, she died of colon adenocarcinoma and its liver metastasis.
M Okada; M Tanaka; N Horiuchi; T Kato; H Tagami
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  80     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:    2000 Sep-Oct
Date Detail:
Created Date:  2001-01-25     Completed Date:  2001-05-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  376-7     Citation Subset:  IM    
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Adenocarcinoma / complications*,  pathology
Carcinoma, Basal Cell / complications,  pathology
Carcinoma, Squamous Cell / complications,  pathology
Colonic Neoplasms / complications*,  pathology
Lymph Nodes / pathology
Middle Aged
Sarcoidosis / complications*,  pathology
Skin / pathology
Skin Diseases / complications*,  pathology
Skin Neoplasms / complications,  pathology
Xeroderma Pigmentosum / complications*,  pathology

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