| Coexistence of pituitary adrenocorticotropin-dependent Cushing's syndrome with a solitary adrenal adenoma. | |
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MedLine Citation:
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PMID: 6246139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 45-yr-old woman presented with a 2-hr history of Cushing's syndrome. Baseline cortisol and ACTH levels were elevated and lacked a normal circadian rhythm. Dynamic testing of her pituitary-adrenal function revealed positive responses to metyrapone and synthetic ACTH and suppression with high doses of dexamethasone. The finding of asymmetrical adrenal uptake of 6-[131I]methyl-19-nor-cholesterol and a tumor image in the right adrenal on venography led to the preoperative diagnosis of pituitary ACTH-dependent adrenal hyperfunction coexisting with a right adrenal adenoma. Surgical resection of the right adrenal demonstrated a solitary 39-g nodule, 4 cm in diameter. There were no additional nodules present in the surrounding cortex. When incubated in vitro, both the adenoma and the surrounding tissue were functional and responsive to ACTH. This was in contrast to the lack of response to ACTH in vitro of similar tissues removed from two other patients with ACTH-independent adrenal adenomas. We suggest that this case represents a transition between pituitary ACTH-dependent bilateral adrenocortical hyperfunction and solitary adrenal adenoma. |
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Authors:
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D E Schteingart; H S Tsao |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 50 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-07-12 Completed Date: 1980-07-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 961-6 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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complications,
diagnosis*,
metabolism Adrenal Gland Neoplasms / complications, diagnosis*, metabolism Adrenocorticotropic Hormone / blood, diagnostic use* Cushing Syndrome / complications, diagnosis*, metabolism Dexamethasone / diagnostic use Female Humans Hydrocortisone / blood Metyrapone / diagnostic use Middle Aged Steroids / urine |
| Chemical | |
Reg. No./Substance:
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0/Steroids; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 54-36-4/Metyrapone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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