| Coexistence of gonadoblastoma and dysgerminoma in a dysgenetic gonad on touch preparation: a case report. | |
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MedLine Citation:
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PMID: 21162092 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Swyer syndrome is known as pure gonadal dysgenesis. Individuals with Swyer syndrome are phenotypically female with unambiguously female genital appearance at birth, and normal Mullerian structures. The condition usually first becomes apparent in adolescence with delayed puberty and amenorrhea due to the fact that the gonads have no hormonal or reproductive potential. These individuals are characterized by 46XY karyotype, primary amenorrhea, tall stature, female external genitalia and normal but hypoestrogenised vagina and cervix. A high incidence of gonadoblastoma and germ cell malignancies has been reported in dysgenetic gonads, and therefore, the current practice is to proceed to a gonadectomy once the diagnosis is made. Herein, we report a case of gonadoblastoma and dysgerminoma diagnosed on touch preparation in a dysgenetic gonad of a 16-year-old patient with Swyer syndrome. |
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Authors:
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Zahra Maleki; Meredith Loveless; Mostafa Fraig |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diagnostic cytopathology Volume: 39 ISSN: 1097-0339 ISO Abbreviation: Diagn. Cytopathol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8506895 Medline TA: Diagn Cytopathol Country: United States |
Other Details:
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Languages: eng Pagination: 42-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Pathology, The Johns Hopkins Pathology, Baltimore, Maryland 21224, USA. zmaleki1@jhmi.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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