Document Detail


Coexistence and function of glutamate receptor subtypes in the horizontal cells of the tiger salamander retina.
MedLine Citation:
PMID:  1661137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of the major glutamate receptor agonists, kainate (KA), alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), quisqualate (QA), N-methyl-D-aspartate (NMDA), L-alpha-amino-4-phosphonobutyrate (L-AP4), and trans-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on horizontal cells (HCs) were studied in superfused larval tiger salamander retina. 20 microM of KA, AMPA, and QA mimicked the action of 3 mM glutamate in the absence and presence of 1 mM Co2+. 20 microM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) blocked the actions of KA and AMPA, but not those of QA and glutamate, indicative of the existence of CNQX-resistant QA receptors in the tiger salamander HCs. Prolonged application of ACPD hyperpolarized the HCs and enhanced the light responses, probably by shifting the resting HC voltage (Er) to a more hyperpolarized position. It is possible that the KA, AMPA, and CNQX-resistant QA receptors are involved in mediating the postsynaptic light responses in HCs, and ACPD receptors are involved in sensitivity adjustment of the HC responses.
Authors:
X L Yang; S M Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Visual neuroscience     Volume:  7     ISSN:  0952-5238     ISO Abbreviation:  Vis. Neurosci.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-01-30     Completed Date:  1992-01-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8809466     Medline TA:  Vis Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  377-82     Citation Subset:  IM    
Affiliation:
Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dark Adaptation
Electrophysiology
Glutamates / pharmacology
Heterocyclic Compounds / pharmacology
Membrane Potentials
Photic Stimulation
Receptors, Glutamate
Receptors, Neurotransmitter / physiology*
Retina / drug effects,  physiology*
Urodela
Grant Support
ID/Acronym/Agency:
EY 04446/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Glutamates; 0/Heterocyclic Compounds; 0/Receptors, Glutamate; 0/Receptors, Neurotransmitter

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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