Document Detail

Coexistence of Bronchiectasis and Rheumatoid Arthritis: Revisited.
MedLine Citation:
PMID:  22782500     Owner:  NLM     Status:  Publisher    
The presence of bronchiectasis in patients with rheumatoid arthritis has been recognised for many decades, but despite this, little research has been undertaken in this area. It is important to recognise that bronchiectasis co-existent with rheumatoid arthritis differs from the other types of bronchiectasis. The purpose of this descriptive review was to delineate the epidemiology, etiology, risk factors, pulmonary function testing, imaging, prognosis and management of concomitant bronchiectasis and rheumatoid arthritis. To inform our study we searched PubMed, EMBASE, CINAHL and Medline using combinations of the following key words: computed tomography, lung function tests, rheumatoid arthritis, bronchiectasis, biological agents, and interstitial lung disease. The number of published papers covering this topic is limited, but several relevant conclusions can be drawn. Patients with concomitant rheumatoid arthritis (RA) and bronchiectasis (BR) have worse obstructive airways disease, increased susceptibility to recurrent pulmonary infections, faster lung function decline and higher mortality compared with subjects with either RA or BR alone. The use of disease-modifying anti-rheumatic drugs (both biological and non-biological) for RA in RA-BR patients imparts a further challenge in managing these patients. Although there are not any published guidelines on the management of coexisting RA-BR we have attempted to provide such recommendations based on the literature review and our experience.
Maria M Wilczynska; Alison M Condliffe; Damian J McKeon
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-10
Journal Detail:
Title:  Respiratory care     Volume:  -     ISSN:  0020-1324     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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