| Coerulear activation by crh and its role in hypertension induced by prenatal malnutrition in the rat. | |
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MedLine Citation:
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PMID: 17464781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of intracoerulear CRH and intraparaventricular prazosin on systolic pressure, diastolic pressure and heart rate were studied in prenatally malnourished hypertensive rats. At day 40 of life, (i) malnourished rats showed enhanced systolic pressure, heart rate, and plasma corticosterone; (ii) intracoerulear CRH increased systolic pressure and heart rate only in controls; (iii) intraparaventricular prazosin decreased systolic pressure and heart rate only in malnourished rats; (iv) in controls, prazosin did not prevent the stimulatory effect of CRH on the cardiovascular parameters; in malnourished rats, prazosin allowed CRH regain its stimulatory effects. Thus, coerulear activation by CRH would be involved in hypertension and tachycardia developed by prenatally malnourished animals. |
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Authors:
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Hernán Pérez; Samuel Ruiz; Héctor Núñez; Allan White; Martin Gotteland |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The International journal of neuroscience Volume: 117 ISSN: 0020-7454 ISO Abbreviation: Int. J. Neurosci. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-27 Completed Date: 2007-06-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 627-42 Citation Subset: IM |
Affiliation:
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Laboratory of Hormones and Receptors, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile. hperez@inta.cl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / administration & dosage Blood Pressure / drug effects Body Weight / drug effects, physiology Corticosterone / blood Corticotropin-Releasing Hormone / administration & dosage* Disease Models, Animal Drug Administration Routes Drug Interactions Female Fetal Nutrition Disorders / physiopathology* Heart Rate / drug effects Hypertension / drug therapy* Locus Coeruleus / drug effects, physiology* Male Paraventricular Hypothalamic Nucleus / drug effects, physiology Prazosin / administration & dosage Pregnancy Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 19216-56-9/Prazosin; 50-22-6/Corticosterone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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