Document Detail


Coerulear activation by crh and its role in hypertension induced by prenatal malnutrition in the rat.
MedLine Citation:
PMID:  17464781     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of intracoerulear CRH and intraparaventricular prazosin on systolic pressure, diastolic pressure and heart rate were studied in prenatally malnourished hypertensive rats. At day 40 of life, (i) malnourished rats showed enhanced systolic pressure, heart rate, and plasma corticosterone; (ii) intracoerulear CRH increased systolic pressure and heart rate only in controls; (iii) intraparaventricular prazosin decreased systolic pressure and heart rate only in malnourished rats; (iv) in controls, prazosin did not prevent the stimulatory effect of CRH on the cardiovascular parameters; in malnourished rats, prazosin allowed CRH regain its stimulatory effects. Thus, coerulear activation by CRH would be involved in hypertension and tachycardia developed by prenatally malnourished animals.
Authors:
Hernán Pérez; Samuel Ruiz; Héctor Núñez; Allan White; Martin Gotteland
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  117     ISSN:  0020-7454     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  627-42     Citation Subset:  IM    
Affiliation:
Laboratory of Hormones and Receptors, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile. hperez@inta.cl
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / administration & dosage
Blood Pressure / drug effects
Body Weight / drug effects,  physiology
Corticosterone / blood
Corticotropin-Releasing Hormone / administration & dosage*
Disease Models, Animal
Drug Administration Routes
Drug Interactions
Female
Fetal Nutrition Disorders / physiopathology*
Heart Rate / drug effects
Hypertension / drug therapy*
Locus Coeruleus / drug effects,  physiology*
Male
Paraventricular Hypothalamic Nucleus / drug effects,  physiology
Prazosin / administration & dosage
Pregnancy
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 19216-56-9/Prazosin; 50-22-6/Corticosterone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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