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Coenzyme q(10) terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study.
MedLine Citation:
PMID:  21462215     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Studies have suggested that micronutrient deficiency has some role in the progression of chronic heart failure (CHF).
HYPOTHESIS: Oral supplementation with coenzyme Q(10) (CoQ(10) ) and creatine may reduce mitochondrial dysfunction that contributes to impaired physical performance in CHF.
METHODS: We conducted a randomized, double-blind, placebo-controlled trial to determine the effect of a mixture of water-soluble CoQ(10) (CoQ(10) terclatrate; Q-ter) and creatine on exercise tolerance and health-related quality of life. Exercise tolerance was measured as total work capacity (kg·m) and peak oxygen consumption (VO(2) , mL/min/kg), both from a cardiopulmonary exercise test. Health-related quality of life was measured by the Sickness Impact Profile (SIP) in CHF secondary to left ventricular systolic dysfunction (left ventricular ejection fraction ≤ 35%). After baseline assessment, 67 patients with stable CHF were randomized to receive Q-ter 320 mg + creatine 340 mg (n = 35) or placebo (n = 32) once daily for 8 weeks.
RESULTS: At multivariate analysis, 8-week peak VO(2) was significantly higher in the active treatment group than in the placebo group (+1.8 ± 0.9 mL/min/kg, 95% CI: 0.1-3.6, P < 0.05). No untoward effects occurred in either group.
CONCLUSIONS: This study suggests that oral Q-ter and creatine, added to conventional drug therapy, exert some beneficial effect on physical performance in stable systolic CHF. Results may support the design of larger studies aimed at assessing the long-term effects of this treatment on functional status and harder outcomes. © 2011 Wiley Periodicals, Inc. The study was supported by an unconditional grant from Scharper Therapeutics, Milan, Italy, which had the responsibility for manufacturing the active treatment and the placebo. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Authors:
Stefano Fumagalli; Francesco Fattirolli; Lorenzo Guarducci; Tommaso Cellai; Samuele Baldasseroni; Francesca Tarantini; Mauro Di Bari; Giulio Masotti; Niccolò Marchionni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  34     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  211-7     Citation Subset:  IM    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
Affiliation:
Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatrics, University of Florence and Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. fumadue@tin.it.
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