| Coenzyme q10 for prevention of anthracycline-induced cardiotoxicity. | |
| | |
MedLine Citation:
|
PMID: 15911925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Preclinical and clinical studies suggest that anthracycline-induced cardiotoxicity can be prevented by administering coenzyme Q10 during cancer chemotherapy that includes drugs such as doxorubicin and daunorubicin. Studies further suggest that coenzyme Q10 does not interfere with the antineoplastic action of anthracyclines and might even enhance their anticancer effects. Preventing cardiotoxicity might allow for escalation of the anthracycline dose, which would further enhance the anticancer effects. Based on clinical investigation, although limited, a cumulative dose of doxorubicin of up to 900 mg/m2, and possibly higher, can be administered safely during chemotherapy as long as coenzyme Q10 is administered concurrently. The etiology of the dose-limiting cardiomyopathy that is induced by anthracyclines can be explained by irreversible damage to heart cell mitochondria, which differ from mitochondria of other cells in that they possess a unique enzyme on the inner mitochondrial membrane. This enzyme reduces anthracyclines to their semiquinones, resulting in severe oxidative stress, disruption of mitochondrial energetics, and irreversible damage to mitochondrial DNA. Damage to mitochondrial DNA blocks the regenerative capability of the organelle and ultimately leads to apoptosis or necrosis of myocytes. Coenzyme Q10, an essential component of the electron transport system and a potent intracellular antioxidant, appears to prevent damage to the mitochondria of the heart, thus preventing the development of anthracycline-induced cardiomyopathy. |
| | |
Authors:
|
Kenneth A Conklin |
Related Documents
:
|
2268345 - A point mutation in the mitochondrial trna(leu)(uur) gene in melas (mitochondrial myopa... 2929595 - An asian-specific 9-bp deletion of mitochondrial dna is frequently found in polynesians. 8817925 - Interdecadal heterogeneity in mitochondrial dna of atlantic haddock (melanogrammus aegl... 19487465 - Human dna2 is a nuclear and mitochondrial dna maintenance protein. 7916985 - Use of representational difference analysis for the identification of mdm2 oncogene amp... 2335225 - Interaction of histones h1 and h1(0) with superhelical and linear dna. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Integrative cancer therapies Volume: 4 ISSN: 1534-7354 ISO Abbreviation: Integr Cancer Ther Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-05-24 Completed Date: 2005-09-29 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101128834 Medline TA: Integr Cancer Ther Country: United States |
Other Details:
|
Languages: eng Pagination: 110-30 Citation Subset: IM |
Affiliation:
|
Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1778, USA. kconklin@mednet.ucla.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anthracyclines / administration & dosage, adverse effects*, pharmacology Antibiotics, Antineoplastic / administration & dosage, adverse effects*, pharmacology Antioxidants / administration & dosage, pharmacology* Cardiomyopathies / chemically induced, drug therapy, prevention & control* Coenzymes Cytoprotection* Dose-Response Relationship, Drug Drug Therapy, Combination Heart / drug effects Heart Failure / prevention & control Humans Mitochondria, Heart / drug effects* Neoplasms / drug therapy Ubiquinone / administration & dosage, analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Anthracyclines; 0/Antibiotics, Antineoplastic; 0/Antioxidants; 0/Coenzymes; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Leg ulcers are a diagnostic and therapeutic challenge.
Next Document: Acupuncture: role in comprehensive cancer care--a primer for the oncologist and review of the litera...