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Coenzyme q(10) and its relation with oxidant and antioxidant system markers in patients with end-stage renal disease.
MedLine Citation:
PMID:  21787158     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Rationale and objectives: Oxidative stress is increased in chronic kidney disease (CKD) patients and end-stage renal disease (ESRD) patients undergoing dialysis treatment. Coenzyme Q(10) (CoQ(10)) is a ubiquitous and strong antioxidant. Role of CoQ(10) is not fully evaluated in renal patients. We aimed to investigate the relationship of CoQ(10) with oxidant and antioxidant system markers in patients with renal disease. Material and methods: Forty patients with CKD (stages 3-5) who were managed conservatively without dialysis treatment, 40 hemodialysis, and 60 chronic ambulatory peritoneal dialysis (CAPD) patients were included in the study. Biochemical and whole blood analyses were done using hospital auto-analyzers from stored samples. Serum CoQ(10), malondialdehyde (MDA), superoxide dismutase (SOD), and antioxidant activity (AOA) levels were determined. Main findings: There was no difference among the groups in terms of serum CoQ(10) levels. However, other components of antioxidant system, namely, SOD and AOA were significantly higher in CAPD patients when compared to CKD patients. MDA levels were not significantly different among the groups. Principal conclusion(s): The results of this study showed no difference among CKD, CAPD, and hemodialysis patients in terms of serum CoQ(10) levels.
Authors:
Hakki Gokbel; Huseyin Atalay; Nilsel Okudan; Yalcin Solak; Muaz Belviranli; Suleyman Turk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  33     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  England    
Other Details:
Languages:  eng     Pagination:  677-81     Citation Subset:  IM    
Affiliation:
Department of Physiology, Meram School of Medicine, Selcuk University , Meram, Konya , Turkey.
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