Document Detail


Coenzyme q and the respiratory chain: coenzyme q pool and mitochondrial supercomplexes.
MedLine Citation:
PMID:  25126045     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Two alternative models of organization of the mitochondrial electron transport chain (mETC) have been alternatively favored or questioned by the accumulation evidences of different sources, the solid model or the random collision model. Both agree in the number of respiratory complexes (I-IV) that participate in the mETC, but while the random collision model proposes that Complexes I-IV do not interact physically and that electrons are transferred between them by coenzyme Q and cytochrome c, the solid model proposes that all complexes super-assemble in the so-called respirasome. Recently, the plasticity model has been developed to incorporate the solid and the random collision model as extreme situations of a dynamic organization, allowing super-assembly free movement of the respiratory complexes. In this review, we evaluate the supporting evidences of each model and the implications of the super-assembly in the physiological role of coenzyme Q.
Authors:
José Antonio Enriquez; Giorgio Lenaz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular syndromology     Volume:  5     ISSN:  1661-8769     ISO Abbreviation:  Mol Syndromol     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-08-15     Completed Date:  2014-08-15     Revised Date:  2014-08-18    
Medline Journal Info:
Nlm Unique ID:  101525192     Medline TA:  Mol Syndromol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  119-40     Citation Subset:  -    
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