Document Detail

Coenzyme alterations in rats with experimental hypertension.
MedLine Citation:
PMID:  185674     Owner:  NLM     Status:  MEDLINE    
The changes in the content of pyridine nucleotide coenzymes (NAD+ and NADH) in several models of experimentally induced hypertension, differing in mechanism (genetic spontaneous hypertension, renal one kidney Goldblatt hypertension, Adrenal-regeneration hypertension after INGLE-HIGGINS and Skelton, and NaC1 hypertension) were studied. An obvious difference between the changes in NAD+ and NADH in the various models of hypertension, was established: Thus in NaC1 hypertension a high level of the coenzymes in the kidneys and in the vessel wall was found, while the liver coenzyme content was in normal ranges. In ARH the coenzyme level was elevated not only in the kidneys and in the vessel wall, but in the liver as well. Treatment with hypotensive antilipolytic prostaglandin E1 decreased the coenzymes in ARH to normal values. Renal hypertension was characterized by a low content of oxidized NAD, an increased NADH, and a decreased NAD+/NADH ratio in the kidneys and the liver, while in the vessel wall the coenzyme level was moderately increased. The coenzyme changes in the kidneys of SHR were similar to those in renal hypertensive rats. However coenzyme level in the vessel wall of SHR was lower than in all the other forms of hypertension.
V T Orbetzova; D Kiprov; A Puchlev
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie     Volume:  167     ISSN:  0300-9130     ISO Abbreviation:  Res Exp Med (Berl)     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0324736     Medline TA:  Res Exp Med (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  61-70     Citation Subset:  IM    
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MeSH Terms
Adrenal Medulla / physiology
Arteries / enzymology
Disease Models, Animal*
Hypertension / chemically induced,  enzymology*
Hypertension, Renal / enzymology
Kidney / enzymology
Liver / enzymology
NAD / metabolism*
Prostaglandins E / pharmacology
Rats, Inbred Strains
Sodium Chloride
Reg. No./Substance:
0/Prostaglandins E; 53-84-9/NAD; 7647-14-5/Sodium Chloride

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