Document Detail

Coenzyme Q10, vitamin E, and dihydrothioctic acid cooperatively prevent diene conjugation in isolated low-density lipoprotein.
MedLine Citation:
PMID:  11229536     Owner:  NLM     Status:  MEDLINE    
Coenzyme Q (Q10) and alpha-tocopherol cooperatively delay the onset of diene conjugation in isolated human low density lipoprotein if supplied in water-soluble preparations to blood serum. Both copper ions and morpholino sydnonimine (in the presence of glucose; SIN-1-glucose) -driven diene conjugation is measurable as soon as both reduced Q10 and tocopherol are oxidized, where tocopherol oxidation starts after 80-90% consumption of reduced Q10. LDL-bound Q10 in turn can be rapidly reduced by dihydrolipoic acid (thioctic acid). This reaction is at least 10 times faster than reduction by ascorbic acid.
D Schneider; E F Elstner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  2     ISSN:  1523-0864     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2000  
Date Detail:
Created Date:  2001-03-02     Completed Date:  2001-06-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-33     Citation Subset:  IM    
Institute of Phytopathology, Department of Applied Biochemistry, Technical University Munich, Freising-Weihenstephen, Germany.
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MeSH Terms
Antioxidants / pharmacology
Ascorbic Acid / pharmacology
Copper / pharmacology
Ions / pharmacology
Lipoproteins, LDL / blood,  metabolism*
Middle Aged
Models, Biological
Molsidomine / analogs & derivatives,  pharmacology
Nitric Oxide Donors / pharmacology
Oxygen / metabolism
Protein Binding
Thioctic Acid / analogs & derivatives*,  pharmacology*
Time Factors
Ubiquinone / analogs & derivatives,  pharmacology*
Vitamin E / pharmacology*
Reg. No./Substance:
0/Antioxidants; 0/Coenzymes; 0/Ions; 0/Lipoproteins, LDL; 0/Nitric Oxide Donors; 1339-63-5/Ubiquinone; 1406-18-4/Vitamin E; 25717-80-0/Molsidomine; 303-98-0/coenzyme Q10; 33876-97-0/3-morpholino-sydnonimine; 462-20-4/dihydrolipoic acid; 50-81-7/Ascorbic Acid; 62-46-4/Thioctic Acid; 7440-50-8/Copper; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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