| Coenzyme Q10, vitamin E, and dihydrothioctic acid cooperatively prevent diene conjugation in isolated low-density lipoprotein. | |
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MedLine Citation:
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PMID: 11229536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coenzyme Q (Q10) and alpha-tocopherol cooperatively delay the onset of diene conjugation in isolated human low density lipoprotein if supplied in water-soluble preparations to blood serum. Both copper ions and morpholino sydnonimine (in the presence of glucose; SIN-1-glucose) -driven diene conjugation is measurable as soon as both reduced Q10 and tocopherol are oxidized, where tocopherol oxidation starts after 80-90% consumption of reduced Q10. LDL-bound Q10 in turn can be rapidly reduced by dihydrolipoic acid (thioctic acid). This reaction is at least 10 times faster than reduction by ascorbic acid. |
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Authors:
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D Schneider; E F Elstner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 2 ISSN: 1523-0864 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2000 |
Date Detail:
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Created Date: 2001-03-02 Completed Date: 2001-06-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 327-33 Citation Subset: IM |
Affiliation:
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Institute of Phytopathology, Department of Applied Biochemistry, Technical University Munich, Freising-Weihenstephen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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pharmacology Ascorbic Acid / pharmacology Coenzymes Copper / pharmacology Humans Ions / pharmacology Lipoproteins, LDL / blood, metabolism* Male Middle Aged Models, Biological Molsidomine / analogs & derivatives, pharmacology Nitric Oxide Donors / pharmacology Oxygen / metabolism Protein Binding Thioctic Acid / analogs & derivatives*, pharmacology* Time Factors Ubiquinone / analogs & derivatives, pharmacology* Vitamin E / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Coenzymes; 0/Ions; 0/Lipoproteins, LDL; 0/Nitric Oxide Donors; 1339-63-5/Ubiquinone; 1406-18-4/Vitamin E; 25717-80-0/Molsidomine; 303-98-0/coenzyme Q10; 33876-97-0/3-morpholino-sydnonimine; 462-20-4/dihydrolipoic acid; 50-81-7/Ascorbic Acid; 62-46-4/Thioctic Acid; 7440-50-8/Copper; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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