| Coenzyme Q(10) supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise. | |
| | |
MedLine Citation:
|
PMID: 21990004 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Exhausting exercise induces muscle damage associated with high production of free radicals and pro-inflammatory mediators. AIM: The objective of this study was to determine for the first time and simultaneously whether oral coenzyme Q(10) (CoQ(10)) supplementation can prevent over-expression of inflammatory mediators and oxidative stress associated with strenuous exercise. METHODS: The participants were classified in two groups: CoQ(10) group (CG) and placebo group (PG). The physical test consisted in a constant run (50 km) that combined several degrees of high effort (mountain run and ultra-endurance), in permanent climbing. RESULTS: Exercise was associated with an increase in TNF-α, IL-6, 8-hydroxy-2'-deoxyguanosine (8-OHdG), and isoprostane levels, revealing the degree of inflammation and oxidative stress induced. Oral supplementation of CoQ(10) during exercise was efficient reducing oxidative stress (decreased membrane hydroperoxides, 8-OHdG and isoprostanes generation, increased catalase, and total antioxidant status), which would lead to the maintenance of the cell integrity. Data obtained also indicate that CoQ(10) prevents over-expression of TNF-α after exercise, together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF. Moreover, CoQ(10) supplementation reduced creatinine production. CONCLUSIONS: CoQ(10) supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signaling, reducing the subsequent muscle damage. |
| | |
Authors:
|
Javier Díaz-Castro; Rafael Guisado; Naroa Kajarabille; Carmen García; Isabel M Guisado; Carlos de Teresa; Julio J Ochoa |
Related Documents
:
|
22234944 - A gender comparison of central and peripheral neuromuscular function after exercise. 21912754 - Previous leisure-time physical activity dose dependently decreases ischemic stroke seve... 8901164 - Hydration assessment during cold-weather military field training exercises. 21892644 - Cognitive function following treadmill exercise in thermal protective clothing. 20388014 - Effects of ovariectomy and resistance training on mmp-2 activity in rat calcaneal tendon. 6755764 - Ethnic differences in beta-1-adrenoceptor sensitivity. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-12 |
Journal Detail:
|
Title: European journal of nutrition Volume: - ISSN: 1436-6215 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888704 Medline TA: Eur J Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Physiology, University of Granada, Granada, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Applying multilevel model to the relationship of dietary patterns and colorectal cancer: an ongoing ...
Next Document: The Cellular Pathology of Lysosomal Diseases.