| Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance. | |
| | |
MedLine Citation:
|
PMID: 22653988 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Statins are cholesterol-lowering drugs widely used in the prevention of cardiovascular diseases; however, they are associated with various types of myopathies. Statins inhibit HMG-CoA reductase and thus decrease biosynthesis of low-density lipoprotein cholesterol and may also reduce ubiquinones, essential coenzymes of a mitochondrial electron transport chain, which contain isoprenoid residues, synthesized through an HMG-CoA reductase-dependent pathway. Therefore, we hypothesized that statin treatment might influence physical performance through muscular mitochondrial dysfunction due to ubiquinone deficiency. Methods and Results: The effect of two statins, atorvastatin and pravastatin, on ubiquinone content, mitochondrial function and physical performance was examined by using statin-treated mice. Changes in energy metabolism in association with statin-treatment were studied by using cultured myocytes. We found that atorvastatin-treated mice developed muscular mitochondrial dysfunction due to ubiquinone deficiency and a decrease in exercise endurance without affecting muscle mass and strength. Meanwhile, pravastatin at ten times higher dose of atorvastatin had no such effects. In cultured myocytes, atorvastatin-related decrease in mitochondrial activity led to a decrease in oxygen utilization and an increase in lactate production. Conversely, coenzyme Q(10) treatment in atorvastatin-treated mice reversed atorvastatin-related mitochondrial dysfunction and a decrease in oxygen utilization, and thus improved exercise endurance. Conclusion: Atorvastatin decreased exercise endurance in mice through mitochondrial dysfunction due to ubiquinone deficiency. Ubiquinone supplementation with coenzyme Q(10) could reverse atorvastatin-related mitochondrial dysfunction and decrease in exercise tolerance. |
| | |
Authors:
|
Ayako Muraki; Kazutoshi Miyashita; Masanori Mitsuishi; Masanori Tamaki; Kumiko Tanaka; Hiroshi Itoh |
Related Documents
:
|
22786458 - Dysfunctional endogenous analgesia during exercise in patients with chronic pain: to ex... 16569978 - A qualitative approach to developing a patient-derived intervention to increase exercis... 21478258 - Histamine-receptor blockade reduces blood flow but not muscle glucose uptake during pos... 12042688 - Effects of long-term exercise rehabilitation on claudication distances in patients with... 21331628 - Phytoestrogens enhance antioxidant enzymes after swimming exercise and modulate sex hor... 9561688 - Effect of exercise on acid-base status of horses. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-5-31 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-6-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Keio University. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of oxygen breathing on micro oxygen bubbles in nitrogen depleted rat adipose tissue at sea le...
Next Document: WHAT CAN COMPUTED TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING TELL US ABOUT VENTILATION?