Document Detail


Coenzyme Q10 levels in maternal plasma and cord blood:correlations with mode of delivery.
MedLine Citation:
PMID:  15133315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Oxygen (O2) plays a critical role in the O2-reduction reactions indispensable for life, but can produce free radicals that are involved in many diseases. Coenzyme Q10 (CoQ10), acting as a redox carrier in the respiratory chain, occupies a central position in the energy metabolism and oxidative defence. Neonates seem to be very subjected to oxidative stress because of their deficient antioxidant systems. DESIGN/METHODS: The aim of the study was to verify whether the mode of delivery may affect CoQ10 levels in the mother and neonate, and thus influence the risk of oxidative damage in the newborn. We measured CoQ10 levels in maternal plasma and cord blood at birth after three different modes of delivery (45 term healthy pregnancies): (1) vaginal in room air (VD) (n = 15); (2) elective caesarean section with general anaesthesia (50% O2 and 50% N2O) (CSg) (n = 15), and (3) elective caesarean section with spinal anaesthesia without O2 (CSs) (n = 15). Our results showed higher levels of Q10 in mothers and neonates with VD (1.29 +/- 0.43 and 0.15 +/- 0.06 microg/ml, respectively) or CSs (1.15 +/- 0.28 and 0.24 +/- 0.06 microg/ml, respectively) when compared to CSg (0.74 +/- 0.28 and 0.07 +/- 0.03 microg/ml, respectively) (p < 0.01). CONCLUSIONS: These data demonstrate that the mode of delivery may affect CoQ(10) levels in mothers and neonates, and thus influence the risk of oxidative damage in the newborn.
Authors:
G Compagnoni; G Lista; B Giuffrè; F Mosca; A Marini
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2004-05-05
Journal Detail:
Title:  Biology of the neonate     Volume:  86     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2004  
Date Detail:
Created Date:  2004-08-12     Completed Date:  2005-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  104-7     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Affiliation:
Department of Neonatology, ICP, Milan, Italy. intensivist@tiscalinet.it
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General
Anesthesia, Obstetrical
Anesthesia, Spinal
Cesarean Section
Delivery, Obstetric / methods*
Female
Fetal Blood / chemistry*
Humans
Oxidative Stress
Pregnancy
Risk Factors
Ubiquinone / blood*
Chemical
Reg. No./Substance:
1339-63-5/Ubiquinone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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