Document Detail


Coenzyme Q10 in pregnancy.
MedLine Citation:
PMID:  8823607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our objectives were to assess the plasma coenzyme Q10 (CoQ10) levels in normal pregnancy, in pregnancy with a spontaneous contractile event, in spontaneous abortion and in threatened abortion. Six hundred and fifteen CoQ10 levels were analyzed in 483 pregnant women: 350 patients were employed to design a normal curve; 66 patients with spontaneous contractile activity underwent two or more CoQ10 analyses in different trimesters; 49 patients presented spontaneous abortion, and 18 patients threatened abortion. The normal curve of plasma CoQ10 levels rises during each trimester of pregnancy, while there is a correspondence between a low CoQ10 level and spontaneous abortion. Furthermore we found a statistically significant difference between the plasma CoQ10 value in spontaneous contractile activity, mainly in the third trimester. We found an increase in the plasma CoQ10 level in relation to the contractile activity of the uterine muscle. Further studies are necessary to explain the involvement of this marker on pregnancy in clinical practice.
Authors:
G Noia; G P Littarru; M De Santis; A Oradei; C Mactromarino; C Trivellini; A Caruso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  11     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1996-11-29     Completed Date:  1996-11-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  264-70     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Catholic University, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / blood*
Abortion, Threatened / blood*
Coenzymes
Female
Gestational Age
Humans
Pregnancy
Regression Analysis
Ubiquinone / analogs & derivatives*,  blood
Uterine Contraction*
Chemical
Reg. No./Substance:
0/Coenzymes; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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