Document Detail


Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  19703336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We aimed to determine the effect of supplementation with coenzyme Q10 on conventional therapy of children with cardiac failure due to idiopathic dilated cardiomyopathy. In a prospective, randomized, double-blinded, placebo-controlled trial, we randomized 38 patients younger than 18 years with idiopathic dilated cardiomyopathy to receive either coenzyme Q10, chosen for 17 patients, or placebo, administered in the remaining 21. Echocardiographic systolic and diastolic function parameters were determined for every patient at baseline, and after 6 months of supplementation. The index score for cardiac failure in children as established in New York was used for assessing the functional class of the patients. After 6 months supplementation, 10 patients randomized to receive coenzyme Q10 showed improvements in the grading of diastolic function, this being significantly more than that achieved by those randomized to the placebo group (p value = 0.011). The mean score for the index of cardiac failure index for those receiving coenzyme Q10 was also lower than the control group (p value = 0.024).Our results, therefore, indicate that administration of coenzyme Q10 is useful in ameliorating cardiac failure in patients with idiopathic dilated cardiomyopathy through its significant effect on improving diastolic function.
Authors:
Armen Kocharian; Reza Shabanian; Mohammad Rafiei-Khorgami; Abdolrazagh Kiani; Giv Heidari-Bateni
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-08-25
Journal Detail:
Title:  Cardiology in the young     Volume:  19     ISSN:  1467-1107     ISO Abbreviation:  Cardiol Young     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-14     Completed Date:  2010-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200019     Medline TA:  Cardiol Young     Country:  England    
Other Details:
Languages:  eng     Pagination:  501-6     Citation Subset:  IM    
Affiliation:
Department of Pediatric Cardiology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Cardiomyopathy, Dilated / complications*
Child
Child, Preschool
Double-Blind Method
Heart Failure / drug therapy*,  etiology*
Humans
Infant
Prospective Studies
Ubiquinone / analogs & derivatives*,  therapeutic use
Vitamins / therapeutic use*
Chemical
Reg. No./Substance:
0/Vitamins; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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