| Coenzyme Q10 improves contractility of dysfunctional myocardium in chronic heart failure. | |
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MedLine Citation:
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PMID: 16873938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is evidence that plasma CoQ(10) levels decrease in patients with advanced chronic heart failure (CHF). OBJECTIVE: To investigate whether oral CoQ(10) supplementation could improve cardiocirculatory efficiency in patients with CHF. METHODS: We studied 21 patients in NYHA class II and III (18M, 3W, mean age 59 +/- 9 years) with stable CHF secondary to ischemic heart disease (ejection fraction 37 +/- 7%), using a double-blind, placebo-controlled cross-over design. Patients were assigned to oral CoQ(10) (100 mg tid) and to placebo for 4 weeks, respectively. RESULTS: CoQ(10) supplementation resulted in a threefold increase in plasma CoQ(10) level (P < 0.0001 vs placebo). Systolic wall thickening score index (SWTI) was improved both at rest and peak dobutamine stress echo after CoQ(10) supplementation (+12.1 and 15.6%, respectively, P < 0.05 vs placebo). Left ventricular ejection fraction improved significantly also at peak dobutamine (15% from study entry P < 0.0001) in relation to a decrease in LV end-systolic volume index (from 57 +/- 7 mL/m(2) to 45 mL/m(2), P < 0.001). Improvement in the contractile response was more evident among initially akinetic (+33%) and hypokinetic (+25%) segments than dyskinetic ones (+6%). Improvement in SWTI was correlated with changes in plasma CoQ(10) levels (r = -0.52, P < 0.005). Peak VO(2) was also improved after CoQ(10) as compared with placebo (+13%, <0.005). No side effects were reported with CoQ(10). CONCLUSIONS: Oral CoQ(10) improves LV contractility in CHF without any side effects. This improvement is associated with an enhanced functional capacity. |
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Authors:
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Romualdo Belardinelli; Andi Muçaj; Francesca Lacalaprice; Maridia Solenghi; Federica Principi; Luca Tiano; Gian Paolo Littarru |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: BioFactors (Oxford, England) Volume: 25 ISSN: 0951-6433 ISO Abbreviation: Biofactors Publication Date: 2005 |
Date Detail:
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Created Date: 2006-07-28 Completed Date: 2006-10-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8807441 Medline TA: Biofactors Country: Netherlands |
Other Details:
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Languages: eng Pagination: 137-45 Citation Subset: IM |
Affiliation:
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Lancisi Heart Institute, Department of Cardiology and Cardiac Surgery, Ancona, Italy. r.belardinelli@fastnet.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiac Output, Low / drug therapy*, physiopathology Chronic Disease / drug therapy Coenzymes Exercise Test Female Humans Male Middle Aged Myocardial Contraction / drug effects* Ubiquinone / analogs & derivatives*, therapeutic use Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Coenzymes; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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