| Coenzyme Q10 and exercise training in chronic heart failure. | |
| | |
MedLine Citation:
|
PMID: 16882678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: There is evidence that plasma coenzyme Q(10) (CoQ(10)) levels decrease in patients with advanced chronic heart failure (CHF). However, it is not known whether oral CoQ(10) supplementation may improve cardiocirculatory efficiency and endothelial function in patients with CHF. METHODS AND RESULTS: We studied 23 patients in NYHA class II and III (20 men, three women, mean age 59+/-9 years) with stable CHF secondary to ischaemic heart disease [ejection fraction 37+/-7%], using a double-blind, placebo-controlled cross-over design. Patients were assigned to each of the following treatments: oral CoQ(10) (100 mg tid), CoQ(10) plus supervised exercise training (ET) (60% of peak VO(2), five times a week), placebo, and placebo plus ET. Each phase lasted 4 weeks. Both peak VO(2) and endothelium-dependent dilation of the brachial artery (EDDBA) improved significantly after CoQ(10) and after ET as compared with placebo. CoQ(10) main effect was: peak VO(2)+9%, EDDBA +38%, systolic wall thickening score index (SWTI) -12%; ET produced comparable effects. CoQ(10) supplementation resulted in a four-fold increase in plasma CoQ(10) level, whereas the combination with ET further increased it. No side effects were reported with CoQ(10). CONCLUSIONS: Oral CoQ(10) improves functional capacity, endothelial function, and LV contractility in CHF without any side effects. The combination of CoQ(10) and ET resulted in higher plasma CoQ(10) levels and more pronounced effects on all the abovementioned parameters. However, significant synergistic effect of CoQ(10) with ET was observed only for peak SWTI suggesting that ET amplifies the already described effect of CoQ(10) on contractility of dysfunctional myocardium. |
| | |
Authors:
|
Romualdo Belardinelli; Andi Muçaj; Francesca Lacalaprice; Maridia Solenghi; Giovanna Seddaiu; Federica Principi; Luca Tiano; Gian Paolo Littarru |
Related Documents
:
|
19122308 - Effectiveness of nocturnal home oxygen therapy to improve exercise capacity, cardiac fu... 11409228 - A comparison of ambulatory oxygen consumption during circuit training and aerobic exerc... 16873938 - Coenzyme q10 improves contractility of dysfunctional myocardium in chronic heart failure. 11150968 - Normal skeletal muscle na(+)-k(+) pump concentration in patients with chronic heart fai... 2354698 - Observations of working postures in garages using the ovako working posture analysing s... 8854708 - Comparison of the respiratory and hemodynamic responses of healthy subjects to exercise... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial Date: 2006-08-01 |
Journal Detail:
|
Title: European heart journal Volume: 27 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2006 Nov |
Date Detail:
|
Created Date: 2006-11-03 Completed Date: 2007-02-07 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
|
Languages: eng Pagination: 2675-81 Citation Subset: IM |
Affiliation:
|
Lancisi Heart Institute, Via Conca, 71 Torrette di Ancona, Italy. r.belardinelli@fastnet.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chronic Disease Coenzymes Double-Blind Method Exercise / physiology* Exercise Therapy Female Heart Failure / enzymology*, therapy Humans Male Middle Aged Ubiquinone / analogs & derivatives*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Coenzymes; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sex-based short- and long-term survival in patients following complicated myocardial infarction.
Next Document: Electrocardiographic risk stratification in families with congenital long QT syndrome.