| Coenzyme Q(10) and Statin Myalgia: What is the Evidence? | |
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MedLine Citation:
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PMID: 20725809 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Statins lower cholesterol by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in the biosynthesis of cholesterol. However, severe adverse events, including myalgias and rhabdomyolysis, have been reported with statin treatment. Different mechanisms have been proposed to explain statin-induced myopathy, including reduction of mevalonate pathway products, induction of apoptosis, mitochondrial dysfunction, and genetic predisposition. A decrease in coenzyme Q(10) (CoQ), a product of the mevalonate pathway, could contribute to statin induced myopathy. This article reviews the clinical and biochemical features of statin-induced myopathy, the inter-relationship between statins and the concentration of CoQ in plasma and tissues, and whether there is a role for supplementation with CoQ to attenuate statin-induced myopathy. |
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Authors:
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Emilie Mas; Trevor A Mori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current atherosclerosis reports Volume: 12 ISSN: 1534-6242 ISO Abbreviation: Curr Atheroscler Rep Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: United States |
Other Details:
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Languages: eng Pagination: 407-13 Citation Subset: IM |
Affiliation:
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School of Medicine and Pharmacology, Royal Perth Hospital Unit, University of Western Australia, Medical Research Foundation Building Level 4, Rear 50, Murray Street, Perth, WA, 6847, Australia. emilie.mas@uwa.edu.au |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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