Document Detail


Coenzyme q10, copper, zinc, and lipid peroxidation levels in serum of patients with chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  21080098     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Severity of chronic obstructive pulmonary disease (COPD) exacerbation is associated with increased level of copper (Cu), zinc (Zn), and lipid peroxidation (malodialdehyde, MDA). The aim of this study was to investigate the levels of lipid peroxidation, Coenzyme Q10 (CoQ10), Zn, and Cu in the COPD exacerbations. Forty-five patients with COPD acute exacerbation and 45 healthy smokers as control group were used in the study. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were lower in exacerbation group than in control. C- reactive protein levels, white blood cell count, and sedimentation rate were significantly (p < 0.001) higher in patients than in control. CoQ10 level and Cu/Zn ratio was significantly (p < 0.05) lower in patients than in control, although MDA, Cu, and Zn levels were significantly (p < 0.05) higher in patients than in control. Negative correlations were found among MDA, Cu, Zn, FEV1, and FVC values in exacerbation and control subjects (p < 0.05). In conclusion, we observed that oxidative stress in the exacerbation period of COPD patients was increased. The decrease in CoQ10 level and Cu/Zn ratio and elevation in Cu and Zn levels observed in the patients probably result from the defense response of organism and are mediated by inflammatory-like substances.
Authors:
Abdullah Cetin Tanrikulu; Abdurrahman Abakay; Osman Evliyaoglu; Yilmaz Palanci
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Publication Detail:
Type:  Journal Article     Date:  2010-11-16
Journal Detail:
Title:  Biological trace element research     Volume:  143     ISSN:  1559-0720     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  659-67     Citation Subset:  IM    
Affiliation:
Department of Chest Disease, Medical Faculty, Dicle University, Diyarbakir, Turkey, cetintanrikulu@hotmail.com.
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