| Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart. | |
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MedLine Citation:
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PMID: 19948181 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Age-related changes in cardiomyocytes reduce the capacity to recover from acute injury or to adapt during chronic disease in advanced age. N-6 polyunsaturated fatty acids (n-6PUFA) lead to higher lipid peroxidation during aging than the less oxidizable monounsaturated fatty acids (MUFA); and coenzyme Q (CoQ)-supplemented n-6PUFA lengthens the lifespan and reduces peroxidation in comparison to non-supplemented n-6PUFA. Here, lifelong feeding on MUFA, n-6PUFA, and n-6 PUFA+CoQ was compared regarding age-related alterations in rat heart. Less mitochondrial area and perimeter were reported for aged n-6 PUFA-fed animals while MUFA led to a higher density of mitochondrial cristae. Mitochondrial complexes and cytochrome c oxidase activity decreased with aging (except complex I and cytochrome c oxidase in n-6 PUFA+CoQ), while increased apoptosis-inducing factor was found with aging. MUFA led to lower mitochondrial DNA-deletion frequency. The lowest hydroperoxide levels for aged animals were found for n-6 PUFA+CoQ, which also showed lower concentrations than did n-6 PUFA. For protein oxidation, specific carbonyl compounds were lower in aged animals; meanwhile lipoxidation-derived protein-oxidation markers were higher. The results suggest that MUFA can protect mitochondria from age-related changes, and that CoQ supplementation to n-6 PUFA partially resembles MUFA benefits. Moreover, under our experimental conditions, lipid-derived oxidative damage appears to be more important than the pure protein-derived oxidative damage during aging. |
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Authors:
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Jos? L Quiles; Reinald Pamplona; M Carmen Ramirez-Tortosa; Alba Naud?; Manuel Portero-Otin; Eduardo Araujo-Nepomuceno; Magdalena L?pez-Fr?as; Maurizio Battino; Julio J Ochoa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-03 |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 131 ISSN: 1872-6216 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 38-47 Citation Subset: IM |
Copyright Information:
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(c) 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Institute of Nutrition and Food Technology Jos? Mataix Verd?, Department of Physiology, University of Granada, Granada, Spain. jlquiles@ugr.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aging / genetics, metabolism Animals Apoptosis Inducing Factor / metabolism DNA, Mitochondrial / metabolism* Diet* Dietary Supplements* Electron Transport Chain Complex Proteins / metabolism Fatty Acids, Monounsaturated / administration & dosage, metabolism* Fatty Acids, Omega-6 / administration & dosage, metabolism* Gene Deletion Lipid Peroxidation / drug effects Male Mitochondria, Heart / drug effects*, metabolism, ultrastructure Myocytes, Cardiac / drug effects*, metabolism, ultrastructure Oxidative Stress / drug effects* Plant Oils / metabolism Protein Carbonylation / drug effects Rats Rats, Wistar Ubiquinone / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Apoptosis Inducing Factor; 0/DNA, Mitochondrial; 0/Electron Transport Chain Complex Proteins; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Omega-6; 0/Pdcd8 protein, rat; 0/Plant Oils; 1339-63-5/Ubiquinone; 8001-21-6/sunflower seed oil; 8001-25-0/olive oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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