Document Detail

Coelomic fluid leptin concentration in normal first-trimester pregnancies and missed miscarriages.
MedLine Citation:
PMID:  16113562     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Investigation of the possible role of leptin in early pregnancy failure. METHODS: Leptin concentration was measured in maternal serum, coelomic fluid and amniotic fluid from 15 singleton pregnancies with live fetuses and 7 missed miscarriages at 7-10 weeks of gestation. RESULTS: In the pregnancies with live fetuses, the median leptin concentration was significantly higher in coelomic fluid (median 33.1 ng/ml) than in maternal serum (median 8.1 ng/ml) or amniotic fluid (median 0.5 ng/ml). In the pregnancies with missed miscarriage, compared to those with live fetuses, the median leptin concentration in coelomic fluid was higher (median 45.3 ng/ml), but in maternal serum it was not significantly different (median 5.5 ng/ml). CONCLUSIONS: The high coelomic fluid leptin concentration suggests that embryonic death may be preceded by impaired oxygenation of the placenta that stimulates production of leptin.
G Makrydimas; H Vandecruys; A Sotiriadis; L Lakasing; K Spencer; K H Nicolaides
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  20     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-08-22     Completed Date:  2005-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  406-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel.
Department of Obstetrics and Gynaecology, Ioannina University Hospital, Ioannina, Greece.
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MeSH Terms
Abortion, Missed / metabolism*
Amniotic Fluid / metabolism*
Fetal Death / metabolism
Leptin / blood,  metabolism*
Oxygen / metabolism
Placenta / metabolism
Pregnancy Trimester, First / metabolism*
Reg. No./Substance:
0/Leptin; 7782-44-7/Oxygen

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