| Coelomic fluid leptin concentration in normal first-trimester pregnancies and missed miscarriages. | |
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MedLine Citation:
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PMID: 16113562 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Investigation of the possible role of leptin in early pregnancy failure. METHODS: Leptin concentration was measured in maternal serum, coelomic fluid and amniotic fluid from 15 singleton pregnancies with live fetuses and 7 missed miscarriages at 7-10 weeks of gestation. RESULTS: In the pregnancies with live fetuses, the median leptin concentration was significantly higher in coelomic fluid (median 33.1 ng/ml) than in maternal serum (median 8.1 ng/ml) or amniotic fluid (median 0.5 ng/ml). In the pregnancies with missed miscarriage, compared to those with live fetuses, the median leptin concentration in coelomic fluid was higher (median 45.3 ng/ml), but in maternal serum it was not significantly different (median 5.5 ng/ml). CONCLUSIONS: The high coelomic fluid leptin concentration suggests that embryonic death may be preceded by impaired oxygenation of the placenta that stimulates production of leptin. |
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Authors:
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G Makrydimas; H Vandecruys; A Sotiriadis; L Lakasing; K Spencer; K H Nicolaides |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 20 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2005 Sep-Oct |
Date Detail:
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Created Date: 2005-08-22 Completed Date: 2005-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 406-9 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2005 S. Karger AG, Basel. |
Affiliation:
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Department of Obstetrics and Gynaecology, Ioannina University Hospital, Ioannina, Greece. grmak@otenet.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Missed
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metabolism* Amniotic Fluid / metabolism* Female Fetal Death / metabolism Humans Leptin / blood, metabolism* Oxygen / metabolism Placenta / metabolism Pregnancy Pregnancy Trimester, First / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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