Document Detail

Coeliac disease and reproductive disorders.
MedLine Citation:
PMID:  20017709     Owner:  NLM     Status:  MEDLINE    
Reproductive problems, such as delayed menarche, amenorrhea, early menopause, infertility, impotence, hypogonadism, recurrent abortions, and low-birth-weight or preterm deliveries, are now known to be among the atypical symptoms of coeliac disease (CD). The pathogenesis of reproductive disorders in CD is unclear, but some hypotheses have been suggested, including autoimmunity and macro- and/or micronutrient deficiency. Recent investigations which have focused on tissue transglutaminase are promising with respect to the clarification of the mechanism of infertility and poor pregnancy outcomes in CD. In this review, the effects of CD on male and female reproductive disorders and pregnancy outcomes are discussed and the need for CD screening in the case of reproductive problems is emphasized.
Bilge Ozgör; Mukadder Ayşe Selimoğlu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  45     ISSN:  1502-7708     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  England    
Other Details:
Languages:  eng     Pagination:  395-402     Citation Subset:  IM    
Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine, Inönü University, Malatya, Turkey.
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MeSH Terms
Celiac Disease / complications*
Infertility, Female / etiology*
Infertility, Male / etiology*
Pregnancy Complications / etiology
Pregnancy Outcome
Risk Factors

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