Document Detail

Coeliac disease is the most common cause of chronic diarrhoea in Iran.
MedLine Citation:
PMID:  15201579     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Coeliac disease (CD) is one of the most important causes of chronic diarrhoea. The prevalence of CD in patients with chronic diarrhoea in Iran remains unknown. The aim of this study was to evaluate the prevalence of CD among 100 Iranian patients with chronic non-bloody diarrhoea. METHODS: One hundred consecutive patients with chronic non-bloody diarrhoea of more than 6 weeks attending an academic centre in Iran were enrolled. Patients with bloody diarrhoea and renal failure were excluded. IgA endomysial antibody (IgA EMA), IgA antigliadin antibody (IgA AGA), and total serum IgA were tested in all patients. Patients with negative IgA EMA were evaluated for other causes of chronic diarrhoea. Patients who had positive IgA EMA underwent upper gastrointestinal endoscopy and duodenal biopsy. Patients with a positive IgA EMA were advised to follow a gluten-free diet (GFD) strictly for 6 months, and then clinical symptoms, serological and haematological tests were re-assessed. RESULTS: A total of 100 patients (55 men and 45 women) with chronic non-bloody diarrhoea were studied. Mean age of the patients was 31 years. Total serum IgA was in the normal range in all participants. Twenty patients (12/45 women; 8/55 men) had positive IgA EMA. Fourteen of them also had a positive IgA AGA. CD was diagnosed in 19 patients (19%). Small intestinal Crohn's disease, small intestinal lymphoma and idiopathic aetiology were the next. In patients with CD, after 6 months of a GFD, 15 patients (75%) had a complete clinical response, three patients (15%) had a good response, and one patient (5%) had a partial response. One patient did not follow a GFD. CONCLUSION: CD is the most common cause of adult chronic non-bloody diarrhoea in Tehran.
Bijan Shahbazkhani; Mehdi Mohamadnejad; Reza Malekzadeh; Mohammad Reza Akbari; Mandana Moghari Esfahani; Siavosh Nasseri-Moghaddam; Masoud Sotoudeh; Amin Elahyfar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  16     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-17     Completed Date:  2005-03-17     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  665-8     Citation Subset:  IM    
Digestive Disease Research Centre, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Autoantibodies / blood
Biological Markers / blood
Celiac Disease / complications*,  diet therapy,  immunology
Chronic Disease
Crohn Disease / complications
Diarrhea / etiology*
Gliadin / immunology
Immunoglobulin A / blood
Muscle Fibers, Skeletal / immunology
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; 0/Immunoglobulin A; 9007-90-3/Gliadin

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