Document Detail

Coeliac disease in spondyloarthropathy: usefulness of serological screening.
MedLine Citation:
PMID:  10791622     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to find unidentified or neglected cases of coeliac disease by using serological screening in a group of patients with spondyloarthropathies. Altogether, 74 consecutively hospitalised patients (28 females, 46 males, from 15 to 72 years of age, mean age 40.4+/-1.6 years) with spondyloarthropathies were investigated by serological screening tests for coeliac disease. IgA- and IgG-type antigliadin antibodies were determined using an enzyme-linked immunosorbent assay, and IgA- and IgG-type antireticulin and IgA-type antiendomysium antibodies were measured by an indirect immunofluorescence method. An increased level of antigliadin antibodies was found in nine (12%) of the studied patients and in one of them, antiendomysium antibodies were revealed. In this HLA B8-positive patient, typical villous atrophy with crypt hyperplasia was found in the small bowel biopsy specimen, which confirmed the diagnosis of coeliac disease. None of the patients had IgA- and IgG-type antireticulin antibodies. We found an association of spondyloarthropathy with coeliac disease in one patient out of 74. Clinicians need to be aware of this association, which has important implications for the correct management of patients.
R Kallikorm; O Uibo; R Uibo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical rheumatology     Volume:  19     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2000  
Date Detail:
Created Date:  2000-06-08     Completed Date:  2000-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  118-22     Citation Subset:  IM    
Department of Internal Medicine, University of Tartu, Estonia.
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MeSH Terms
Celiac Disease / blood,  complications*,  diagnosis
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique, Indirect
Gliadin / immunology
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Middle Aged
Reticulin / immunology
Serologic Tests
Spondylitis, Ankylosing / blood,  complications*,  diagnosis
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Reticulin; 9007-90-3/Gliadin

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