Document Detail

Coeliac disease in irritable bowel syndrome (Rome III) in Southeast Iran.
MedLine Citation:
PMID:  22560821     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND AND STUDY AIMS: Irritable bowel syndrome (IBS) is a common functional gastrointestinal (GI) disorder and coeliac disease (CD) is an auto-immune enteropathy that can mimic almost any functional GI disorder. Both IBS and coeliac disease share common symptoms. The aim of the present study was to estimate the prevalence of CD in patients with IBS and its sub-types.
PATIENTS AND METHODS: In this cross-sectional study (2008-2010), all consecutive patients with IBS who fulfilled the Rome III criteria attending the GI units in Zahedan (Southeast Iran) were included. Patients based on the sub-type of IBS were classified as diarrhoea-predominant irritable bowel syndrome (D-IBS), constipation-predominant irritable bowel syndrome (C-IBS) and alternating symptoms (mixed type). Immunoglobulin A (IgA) tissue transglutaminase (anti-tTG) was used to screen patients for CD. In the case of positive serologic test, duodenal biopsies were taken to confirm the diagnosis.
RESULTS: A total of 364 (221 females and 143 males) patients with IBS were included. The mean±standard deviation (SD) age of patients was 37.4±12.4years. Twenty (5.5%) patients were found to have positive IgA anti-tTG. Main symptoms of patients were diarrhoea (11/20), bloating (10/20) and abdominal distension (6/20). Thirteen (10.5%) patients were found to have positive IgA anti-tTG among the D-IBS, two (1.6%) in the C-IBS and five (4.2%) in M-IBS groups.
CONCLUSION: The prevalence of CD in IBS is high. IBS subjects whose main complaint is diarrhoea, bloating or even abdominal distension should be evaluated for CD.
Alireza Bakhshipour; Seyyed Kazem Nezam; Zahra Zakeri; Reza Gharibi; Ali Bahari; Mahmoud Ali Kaykhaei
Publication Detail:
Type:  Journal Article     Date:  2012-04-04
Journal Detail:
Title:  Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology     Volume:  13     ISSN:  2090-2387     ISO Abbreviation:  Arab J Gastroenterol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-05-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101298363     Medline TA:  Arab J Gastroenterol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  24-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Arab Journal of Gastroenterology. Published by Elsevier Ltd. All rights reserved.
Department of Medicine, Zahedan University of Medical Sciences, Zahedan, Sistan and Balouchestan Province, Iran.
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