Document Detail

Coeliac disease, gluten-free diet, and malignancy.
MedLine Citation:
PMID:  789184     Owner:  NLM     Status:  MEDLINE    
Two hundred and two patients with coeliac disease or idiopathic steatorrhoea previously reported from this unit have been reviewed after a further 10 years of follow-up. Of 20 more deaths, 10 were due to malignancy. A separate study was made of all patients with histologically confirmed coeliac disease seen to the end of 1972 and followed up to the end of 1974. Twenty-one of the 43 deaths in this series were due to malignant tumours, of which 13 were reticulum cell sarcomas. There was no evidence that patients showing sub-optimal clinical response to gluten withdrawal or persisting falt jejunal biopsies were more prone to die of cancer. A gluten-free diet did not appear to be effective in preventing malignant complications, but a longer follow-up of patients will be necessary to provide a final answer to this question.
G K Holmes; P L Stokes; T M Sorahan; P Prior; J A Waterhouse; W T Cooke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  17     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-12-30     Completed Date:  1976-12-30     Revised Date:  2012-05-09    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  612-9     Citation Subset:  AIM; IM    
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MeSH Terms
Celiac Disease / complications*,  diet therapy,  pathology
Follow-Up Studies
Gastrointestinal Neoplasms / etiology*
Lymphoma / etiology
Lymphoma, Large B-Cell, Diffuse / etiology
Middle Aged
Neoplasms / epidemiology
Precancerous Conditions
Reg. No./Substance:

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