Document Detail

Coeliac disease is associated with intrauterine growth and neonatal infections.
MedLine Citation:
PMID:  11883814     Owner:  NLM     Status:  MEDLINE    
To investigate whether factors in the fetal or neonatal period influence the risk of later development of coeliac disease we conducted a population-based register study. The Swedish Medical Birth Register was linked with the Hospital Discharge Register and identified 3392 singleton infants born in the period 1987-97 who developed coeliac disease. Perinatal data for these children were compared with all children born in these years. Exposure variables: Maternal age, parity and smoking habits in early pregnancy, preeclampsia, pregnancy duration and birthweight, birthweight by gestational week, Apgar score, neonatal icterus, neonatal infections, maternal-fetal blood group incompatibility, exchange transfusion, phototherapy. Odds ratios and test-based confidence intervals were calculated. Analyses were made with stratification for year of birth and other risk factors. The risk of developing coeliac disease decreased with maternal age and was lower in first-born than in second-born children. Maternal smoking in early pregnancy was a weak risk factor, as was low birthweight. The most evident risk factors were being exposed to neonatal infections (OR = 1.52, confidence limits 1.19: 1.95) and being small for gestational age (OR = 1.45, confidence limits 1.20; 1.75). These risk factors were independent of each other. Conclusions: We have demonstrated that the intrauterine environment, mainly as mirrored by a low birthweight for gestational age and, independently, neonatal infection diagnosis, is associated with the risk of developing coeliac disease, supporting the idea of a multifactorial aetiology of the disease.
S Sandberg-Bennich; G Dahlquist; B Källén
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  91     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2002  
Date Detail:
Created Date:  2002-03-08     Completed Date:  2002-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  30-3     Citation Subset:  IM    
Department of Medicine, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Bacterial Infections / diagnosis,  epidemiology*
Birth Weight
Celiac Disease / diagnosis,  epidemiology*
Confidence Intervals
Fetal Growth Retardation / diagnosis,  epidemiology*
Infant, Newborn
Infant, Small for Gestational Age
Maternal Age
Odds Ratio
Population Surveillance
Prenatal Diagnosis
Risk Assessment
Risk Factors
Smoking / adverse effects
Sweden / epidemiology
Comment In:
Acta Paediatr. 2002;91(1):16-7   [PMID:  11883812 ]

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