Document Detail

Codon usage, transfer RNA availability and mistranslation in amino acid starved bacteria.
MedLine Citation:
PMID:  1713477     Owner:  NLM     Status:  MEDLINE    
The fidelity of codon reading was examined in amino acid starved Escherichia coli. In one case the level of misincorporation of methionine was measured at an isoleucine residue encoded by either the commonly used AUU codon or the rarely used AUA codon. In this situation we found the frequency of methionine misincorporation to be very low and to be unaffected by the identity of the isoleucine codon. In other experiments histidine misincorporation for glutamine was measured in glutamine starved cells with normal levels of histidine-specific tRNA and cells overproducing this tRNA. Cells overproducing the tRNA had higher levels of misincorporation.
A K Ulrich; L Y Li; J Parker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1089     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-09-04     Completed Date:  1991-09-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  362-6     Citation Subset:  IM    
Department of Microbiology, Southern Illinois University, Carbondale 62901.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Capsid / genetics
Electrophoresis, Gel, Two-Dimensional
Escherichia coli / genetics,  metabolism*
Glutamine / metabolism*
Isoleucine / genetics
Molecular Sequence Data
Protein Biosynthesis*
RNA, Bacterial
RNA, Transfer, His / metabolism*
Grant Support
Reg. No./Substance:
0/Codon; 0/RNA, Bacterial; 0/RNA, Transfer, His; 56-85-9/Glutamine; 73-32-5/Isoleucine

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