| Codon usage, transfer RNA availability and mistranslation in amino acid starved bacteria. | |
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MedLine Citation:
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PMID: 1713477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fidelity of codon reading was examined in amino acid starved Escherichia coli. In one case the level of misincorporation of methionine was measured at an isoleucine residue encoded by either the commonly used AUU codon or the rarely used AUA codon. In this situation we found the frequency of methionine misincorporation to be very low and to be unaffected by the identity of the isoleucine codon. In other experiments histidine misincorporation for glutamine was measured in glutamine starved cells with normal levels of histidine-specific tRNA and cells overproducing this tRNA. Cells overproducing the tRNA had higher levels of misincorporation. |
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Authors:
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A K Ulrich; L Y Li; J Parker |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1089 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-09-04 Completed Date: 1991-09-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 362-6 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Southern Illinois University, Carbondale 62901. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Base Sequence Capsid / genetics Codon* Electrophoresis, Gel, Two-Dimensional Escherichia coli / genetics, metabolism* Glutamine / metabolism* Isoleucine / genetics Molecular Sequence Data Protein Biosynthesis* RNA, Bacterial RNA, Transfer, His / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM25855/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Codon; 0/RNA, Bacterial; 0/RNA, Transfer, His; 56-85-9/Glutamine; 73-32-5/Isoleucine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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