Document Detail

Cod liver oil alters platelet-arterial wall response to injury in pigs.
MedLine Citation:
PMID:  1387590     Owner:  NLM     Status:  MEDLINE    
In 36 normolipemic pigs randomized to a 4-week feeding with regular pig chow (n = 18, control group) or chow supplemented with cod liver oil (1 ml/kg per day) (n = 18, treated group), treatment with cod liver oil produced a significant decrease in serum cholesterol, low density lipoprotein cholesterol, and triglycerides. Deep carotid arterial wall injury (media exposed) by balloon angioplasty was associated with less 111In-labeled platelet deposition (24.6 +/- 4.8 x 10(6)/cm2 versus 62.5 +/- 17.0 x 10(6)/cm2, p less than 0.05; difference, -33.8 x 10(6)/cm2; 95% confidence interval [CI], -1.9 x 10(6)/cm2 to -73.9 x 10(6)/cm2) and injury-related vasoconstriction (21.3 +/- 2.2% versus 30.9 +/- 2.9%, p less than 0.05; difference, -9.6%; 95% CI, -2.2% to -17.0%) in the cod liver oil-treated group than in the control group; with mild injury (media not exposed), platelet deposition was low and unchanged (6.2 +/- 0.5 x 10(6)/cm2 versus 7.8 +/- 0.7 x 10(6)/cm2; difference, -1.6 x 10(6)/cm2; 95% CI, -1.1 x 10(6)/cm2 to +4.3 x 10(6)/cm2), but associated vasoconstriction was reduced respectively (16.3 +/- 2.0% versus 23.0 +/- 2.2%, p less than 0.05; difference, -6.7%; 95% CI, -0.6% to -12.8%). When arterial blood from cod liver oil-treated pigs superfused normal aortic media ex vivo, platelet deposition onto the normal aortic media was lower than when arterial blood from control pigs superfused the normal aortic media (43.7 +/- 8.8 x 10(6)/cm2 versus 66.8 +/- 13.0 x 10(6)/cm2, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
J Y Lam; J J Badimon; R D Ellefson; V Fuster; J H Chesebro
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation research     Volume:  71     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-10-08     Completed Date:  1992-10-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  769-75     Citation Subset:  IM    
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minn.
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MeSH Terms
Angioplasty, Balloon
Arachidonic Acid / blood
Arteries / drug effects*,  injuries,  physiology
Biochemical Phenomena
Bleeding Time
Blood Platelets / drug effects*,  physiology
Carotid Arteries / drug effects
Carotid Artery Injuries
Cod Liver Oil / pharmacology*
Eicosapentaenoic Acid / blood
Fatty Acids / blood
Lipids / blood
Prospective Studies
Random Allocation
Reg. No./Substance:
0/Fatty Acids; 0/Lipids; 1553-41-9/Eicosapentaenoic Acid; 506-32-1/Arachidonic Acid; 8001-69-2/Cod Liver Oil

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