| Cocoa-enriched diets modulate intestinal and systemic humoral immune response in young adult rats. | |
| | |
MedLine Citation:
|
PMID: 21462334 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Scope: Previous studies have shown that a highly enriched cocoa diet affects both intestinal and systemic immune function in young rats. The aim of this study was to elucidate whether diets containing lower amounts of cocoa could also influence the systemic and intestinal humoral immune response. Methods and results: Fecal and serum samples were collected during the study and, at the end, intestinal washes were obtained and mesenteric lymph nodes and small-intestine walls were excised for gene expression assessment. IgA, IgM, IgG1, IgG2a, IgG2b and IgG2c concentrations were quantified in serum whereas S-IgA and S-IgM were determined in feces and intestinal washes. Animals receiving 5 and 10% cocoa for 3 wk showed no age-related increase in serum IgG1 and IgG2a concentrations, and IgG2a values were significantly lower than those in reference animals. Serum IgM was also decreased by the 10% cocoa diet. The 5 and 10% cocoa diets dramatically reduced intestinal S-IgA concentration and modified the expression of several genes involved in IgA synthesis. A diet containing 2% cocoa had no effect on most of the studied variables. Conclusion: The results demonstrate the downregulatory effect of a 5% or higher cocoa diet on the systemic and intestinal humoral immune response in adult rats. |
| | |
Authors:
|
Teresa Pérez-Berezo; Angels Franch; Sara Ramos-Romero; Cristina Castellote; Francisco J Pérez-Cano; Margarida Castell |
Related Documents
:
|
14694304 - Gastric emptying function after ileal j pouch-anal anastomosis for ulcerative colitis. 3605074 - Pocked erythrocyte counts in patients with hereditary spherocytosis before and after sp... 1434914 - Balance studies and polymeric glucose solution to optimize therapy after massive intest... 804274 - Reversal of severe fatty hepatic infiltration after intestinal bypass for morbid obesit... 21986524 - High fat diet induced downregulation of microrna-467b increased lipoprotein lipase in h... 514084 - Increased dietary calcium lowers blood pressure in the spontaneously hypertensive rat. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-4 |
Journal Detail:
|
Title: Molecular nutrition & food research Volume: - ISSN: 1613-4133 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Toxicology and risk assessment of 5-Hydroxymethylfurfural in food.
Next Document: Antioxidant-rich coffee reduces DNA damage, elevates glutathione status and contributes to weight co...