Document Detail

Cockroach diuretic hormones: characterization of a calcitonin-like peptide in insects.
MedLine Citation:
PMID:  10841553     Owner:  NLM     Status:  MEDLINE    
Insect diuretic hormones are crucial for control of water balance. We isolated from the cockroach Diploptera punctata two diuretic hormones (DH), Dippu-DH(31) and Dippu-DH(46), which increase cAMP production and fluid secretion in Malpighian tubules of several insect species. Dippu-DH(31) and -DH(46) contain 31 and 46 amino acids, respectively. Dippu-DH(46) belongs to the corticotropin-releasing factor (CRF)-like insect DH family, whereas Dippu-DH(31) has little sequence similarity to the CRF-like DH, but is similar to the calcitonin family. Dippu-DH(46) and -DH(31) have synergistic effects in D. punctata but have only additive effects in Locusta migratoria. Dippu-DH(31) represents a distinct type of insect DH with actions that differ from those of previously identified insect peptides with diuretic activity.
K Furuya; R J Milchak; K M Schegg; J Zhang; S S Tobe; G M Coast; D A Schooley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  97     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-13     Completed Date:  2000-07-13     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6469-74     Citation Subset:  IM    
Department of Biochemistry, University of Nevada, Reno, NV 89557-0014, USA.
Data Bank Information
Bank Name/Acc. No.:
SWISSPROT/P82372;  P82373
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MeSH Terms
Amino Acid Sequence
Calcitonin / isolation & purification*,  pharmacology
Cockroaches / chemistry*
Corticotropin-Releasing Hormone / pharmacology
Cyclic AMP / biosynthesis
Diuretics / isolation & purification*,  pharmacology
Molecular Sequence Data
Grant Support
Reg. No./Substance:
0/Diuretics; 60-92-4/Cyclic AMP; 9007-12-9/Calcitonin; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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