| Cochlear outer hair cell motility. | |
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MedLine Citation:
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PMID: 18195086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal hearing depends on sound amplification within the mammalian cochlea. The amplification, without which the auditory system is effectively deaf, can be traced to the correct functioning of a group of motile sensory hair cells, the outer hair cells of the cochlea. Acting like motor cells, outer hair cells produce forces that are driven by graded changes in membrane potential. The forces depend on the presence of a motor protein in the lateral membrane of the cells. This protein, known as prestin, is a member of a transporter superfamily SLC26. The functional and structural properties of prestin are described in this review. Whether outer hair cell motility might account for sound amplification at all frequencies is also a critical question and is reviewed here. |
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Authors:
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Jonathan Ashmore |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Physiological reviews Volume: 88 ISSN: 0031-9333 ISO Abbreviation: Physiol. Rev. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-15 Completed Date: 2008-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231714 Medline TA: Physiol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 173-210 Citation Subset: IM |
Affiliation:
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Department of Physiology and UCL Ear Institute, University College London, London, United Kingdom. j.ashmore@ucl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Auditory Perception / physiology Cell Movement / physiology Cochlea / cytology, physiology* Hair Cells, Auditory, Outer / physiology* Membrane Potentials / physiology Mice Mice, Knockout Molecular Motor Proteins / genetics, physiology Organ of Corti / cytology, physiology |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Molecular Motor Proteins; 0/Pres protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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