Document Detail

Cochlear outer hair cell electromotility can provide force for both low and high intensity distortion product otoacoustic emissions.
MedLine Citation:
PMID:  9872135     Owner:  NLM     Status:  MEDLINE    
It is generally believed that the force for the otoacoustic emission (OAE) generation is provided by a mechanism of electromotility, observed in isolated cochlear outer hair cells (OHCs). OHC electromotility is resistant to several ototoxic reagents, it does not depend on ATP hydrolysis, but it can be blocked by specific sulfhydryl reagents: p-chloromercuriphenylsulfonic acid (pCMPS) and p-hydroxymercuriphenylsulfonic acid (pHMPS). We have used these reagents to test whether they also affect OAE. Application of pCMPS and pHMPS on the round window membrane of anesthetized guinea pigs produced a dose-dependent inhibition of the cubic (2F1-F2) distortion product OAE (DPOAE). The inhibition developed progressively from high to low frequencies, reflecting the diffusion of the drugs through the cochlear compartment. The effect of pCMPS and pHMPS was different from the effects of furosemide and lethal anoxia, which impair cochlear function but do not block OHC electromotility. pHMPS suppressed DPOAE completely at all sound intensities tested (45-80 dB SPL), whereas furosemide or lethal anoxia caused DPOAE to disappear at low-level stimulation (45-60 dB SPL) only. Our results suggest that the OHC electromotility might provide the force for DPOAE generation not only at low, but also at high stimulus intensities.
G I Frolenkov; I A Belyantseva; M Kurc; M A Mastroianni; B Kachar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hearing research     Volume:  126     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-16     Completed Date:  1999-03-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  67-74     Citation Subset:  IM    
Section on Structural Cell Biology, Laboratory of Cellular Biology, NIDCD-NIH, Bethesda, MD 20852-3320, USA.
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MeSH Terms
4-Chloromercuribenzenesulfonate / pharmacology
Anoxia / physiopathology
Cell Movement / physiology
Cochlea / cytology,  physiology*
Furosemide / pharmacology
Guinea Pigs
Hair Cells, Auditory, Outer / physiology*
Otoacoustic Emissions, Spontaneous / drug effects,  physiology*
Oxidants / pharmacology
Phenylmercury Compounds / pharmacology
Sulfhydryl Compounds / pharmacology
Reg. No./Substance:
0/Oxidants; 0/Phenylmercury Compounds; 0/Sulfhydryl Compounds; 17781-34-9/4-hydroxymercuribenzenesulfonate; 54-31-9/Furosemide; 554-77-8/4-Chloromercuribenzenesulfonate

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