| Cochlear neuronal populations in developmental defects of the inner ear. Implications for cochlear implantation. | |
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MedLine Citation:
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PMID: 3156467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A histological study was made to determine the cochlear neuronal populations of 20 human ears having hearing loss caused by developmental defects. The neuronal populations ranged from 7677 in an ear with Mondini dysplasia to 30 753 in an ear with DiGeorge's syndrome, the norm for young human subjects being 35 000 neurons. The length of the cochlear (spiral) ganglion varied from 7.3 mm to 14.8 mm, the norm for human subjects being 12 mm. The sensorineural hearing losses in all cases were attributable to malformation or degeneration of the sensorineural structures. The hearing loss was moderate in one case of Alport's syndrome, severe in one case of Usher's syndrome and in one case of severe Mondini dysplasia; it was profound in one case of maternal rubella, one of congenital deafness of unknown cause, another case of severe Mondini dysplasia and one of Down's syndrome (Trisomy 21). One case of mild Mondini dysplasia and one of DiGeorge's syndrome were known to have normal hearing. In 4 other cases hearing status was absent. |
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Authors:
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J M Schmidt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta oto-laryngologica Volume: 99 ISSN: 0001-6489 ISO Abbreviation: Acta Otolaryngol. Publication Date: 1985 Jan-Feb |
Date Detail:
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Created Date: 1985-04-02 Completed Date: 1985-04-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 14-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Cell Count Child, Preschool Cochlea / abnormalities, cytology* Cochlear Implants* Deafness / congenital*, pathology DiGeorge Syndrome / pathology Down Syndrome / pathology Female Hair Cells, Auditory / cytology Humans Infant Infant, Newborn Klippel-Feil Syndrome / pathology Male Middle Aged Nephritis, Hereditary / pathology Neurons / cytology Organ of Corti / abnormalities Retinitis Pigmentosa / pathology Rubella / congenital Spiral Ganglion / cytology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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