Document Detail


Cochlear fluid space dimensions for six species derived from reconstructions of three-dimensional magnetic resonance images.
MedLine Citation:
PMID:  10522939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To establish the dimensions and volumes of the cochlear fluid spaces. STUDY DESIGN: Fluid space volumes, lengths, and cross-sectional areas were derived for the cochleas from six species: human, guinea pig, bat, rat, mouse, and gerbil. METHODS: Three-dimensional reconstructions of the fluid spaces were made from magnetic resonance microscopy (MRM) images. Consecutive serial slices composed of isotropic voxels (25 microm3) representing the entire volume of fixed, isolated cochleas were obtained. The boundaries delineating the fluid spaces, including Reissner's membrane, were resolved for all specimens, except for the human, in which Reissner's membrane was not consistently resolved. Three-dimensional reconstructions of the endolymphatic and perilymphatic fluid spaces were generated. Fluid space length and variation of cross-sectional area with distance were derived by an algorithm that followed the midpoint of the space along the length of the spiral. The total volume of each fluid space was derived from a voxel count for each specimen. RESULTS: Length, volume, and cross-sectional areas are provided for six species. In all cases, the length of the endolymphatic fluid space was consistently longer than that of either perilymphatic scala, primarily as a result of a greater radius of curvature. For guinea pig specimens, the measured volumes of the fluid spaces were considerably lower than those suggested by previous reports based on histological data. CONCLUSIONS: The quantification of cochlear fluid spaces provided by this study will enable the more accurate calculation of drug and other solute movements in fluids of the inner ear during experimental or clinical manipulations.
Authors:
M Thorne; A N Salt; J E DeMott; M M Henson; O W Henson; S L Gewalt
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Laryngoscope     Volume:  109     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-10-26     Completed Date:  1999-10-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1661-8     Citation Subset:  IM; S    
Affiliation:
Department of Otolaryngology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Fluids*
Chiroptera
Cochlea / anatomy & histology*
Endolymphatic Sac / anatomy & histology
Gerbillinae
Guinea Pigs
Humans
Magnetic Resonance Imaging*
Mice
Rats
Scala Tympani / anatomy & histology
Vestibule, Labyrinth / anatomy & histology*
Grant Support
ID/Acronym/Agency:
R01 DC00114/DC/NIDCD NIH HHS; R01 DC01368/DC/NIDCD NIH HHS; T32 DC00022/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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