| Cochlear fluid space dimensions for six species derived from reconstructions of three-dimensional magnetic resonance images. | |
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MedLine Citation:
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PMID: 10522939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To establish the dimensions and volumes of the cochlear fluid spaces. STUDY DESIGN: Fluid space volumes, lengths, and cross-sectional areas were derived for the cochleas from six species: human, guinea pig, bat, rat, mouse, and gerbil. METHODS: Three-dimensional reconstructions of the fluid spaces were made from magnetic resonance microscopy (MRM) images. Consecutive serial slices composed of isotropic voxels (25 microm3) representing the entire volume of fixed, isolated cochleas were obtained. The boundaries delineating the fluid spaces, including Reissner's membrane, were resolved for all specimens, except for the human, in which Reissner's membrane was not consistently resolved. Three-dimensional reconstructions of the endolymphatic and perilymphatic fluid spaces were generated. Fluid space length and variation of cross-sectional area with distance were derived by an algorithm that followed the midpoint of the space along the length of the spiral. The total volume of each fluid space was derived from a voxel count for each specimen. RESULTS: Length, volume, and cross-sectional areas are provided for six species. In all cases, the length of the endolymphatic fluid space was consistently longer than that of either perilymphatic scala, primarily as a result of a greater radius of curvature. For guinea pig specimens, the measured volumes of the fluid spaces were considerably lower than those suggested by previous reports based on histological data. CONCLUSIONS: The quantification of cochlear fluid spaces provided by this study will enable the more accurate calculation of drug and other solute movements in fluids of the inner ear during experimental or clinical manipulations. |
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Authors:
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M Thorne; A N Salt; J E DeMott; M M Henson; O W Henson; S L Gewalt |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Laryngoscope Volume: 109 ISSN: 0023-852X ISO Abbreviation: Laryngoscope Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-10-26 Completed Date: 1999-10-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1661-8 Citation Subset: IM; S |
Affiliation:
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Department of Otolaryngology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Fluids* Chiroptera Cochlea / anatomy & histology* Endolymphatic Sac / anatomy & histology Gerbillinae Guinea Pigs Humans Magnetic Resonance Imaging* Mice Rats Scala Tympani / anatomy & histology Vestibule, Labyrinth / anatomy & histology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DC00114/DC/NIDCD NIH HHS; R01 DC01368/DC/NIDCD NIH HHS; T32 DC00022/DC/NIDCD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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