| Cochlear blood flow autoregulation in Wistar-Kyoto rats. | |
| | |
MedLine Citation:
|
PMID: 2793614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Wistar-Kyoto rats (WKY) were intra-arterially infused with angiotensin II (AII) or phenylephrine for 10 min. Both vasoactive compounds produced an initial increase in cochlear blood flow (CoBF) as measured by laser Doppler flowmetry, followed by a slow steady return to baseline, despite sustained elevations in systemic blood pressure. These results suggest autoregulation of CoBF in the WKY rat. In a second experiment. All was infused directly into the anterior inferior cerebellar artery (AICA) which feeds the cochlear artery. Significant reductions in CoBF were noted without changes in systemic blood pressure. Pretreatment with the specific angiotensin-receptor antagonist, sarthran (Sar1, Thr8-AII), diminished subsequent AII-induced reductions in CoBF. These results indicate that AII binding to vascular receptors may induce vasoconstriction in the supplying vessels of the cochlea, and thus, the interaction of blood-borne AII and vascular angiotensin receptors may participate in the autoregulation of CoBF. |
| | |
Authors:
|
W S Quirk; H A Dengerink; J K Coleman; J W Wright |
Related Documents
:
|
7018814 - The effects of meclofenamate, captopril and phentolamine on organ blood flow in the con... 1665404 - Endothelin-1-induced renal vasoconstriction is blunted by enalaprilat and enhanced by e... 1266974 - Renal effect of meclofenamate in presence and absence of superfusion bioassay. 19181754 - Intra-aortic balloon pumping increases renal blood flow in patients with low left ventr... 19681764 - Use of the retinal vessel analyzer in ocular blood flow research. 21223294 - Platelet concentrates from fresh or overnight-stored blood, an international study. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Hearing research Volume: 41 ISSN: 0378-5955 ISO Abbreviation: Hear. Res. Publication Date: 1989 Aug |
Date Detail:
|
Created Date: 1989-11-07 Completed Date: 1989-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7900445 Medline TA: Hear Res Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 53-60 Citation Subset: IM |
Affiliation:
|
Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II
/
analogs & derivatives,
pharmacology* Animals Blood Flow Velocity* / drug effects* Blood Pressure / drug effects* Cochlea / blood supply*, drug effects, physiology Male Phenylephrine / pharmacology* Rats Rats, Inbred Strains Receptors, Angiotensin / antagonists & inhibitors, drug effects, physiology Vasoconstrictor Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Angiotensin; 0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II; 56832-47-4/angiotensin II, Sar(1)-Thr(8)-; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential susceptibility to gentamicin ototoxicity between albino and pigmented guinea pigs.
Next Document: A computational model for rate-level functions from cat auditory-nerve fibers.