Document Detail

Coccidioidomycosis: evaluation of parameters used to predict outcome with amphotericin B therapy.
MedLine Citation:
PMID:  7099244     Owner:  NLM     Status:  MEDLINE    
A literature review of case histories describing the use of amphotericin B for the treatment of disseminated coccidioidomycosis was performed to detect parameters that were predictive of therapeutic outcome. Several factors were significantly different between patients who were well during prolonged follow-up versus those with active or recurrent disease: 1) mean complement fixation (CF) titer before treatment was lower in patients who were well; 2) well patients had a greater magnitude fall in CF titer during the amphotericin B therapy; 3) mean CF titer after amphotericin B treatment was lower in patients who were well; and 4) patients with a positive coccidioidin skin test before therapy were more likely to be well at 6 months. There was no correlation between total amphotericin B dose or duration of therapy and therapeutic outcome.
M H Hardenbrook; S L Barriere
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mycopathologia     Volume:  78     ISSN:  0301-486X     ISO Abbreviation:  Mycopathologia     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505689     Medline TA:  Mycopathologia     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  65-71     Citation Subset:  IM    
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MeSH Terms
Amphotericin B / therapeutic use*
Antibodies, Fungal / analysis
Coccidioides / immunology
Coccidioidomycosis / drug therapy*
Complement Fixation Tests
Middle Aged
Time Factors
Reg. No./Substance:
0/Antibodies, Fungal; 1397-89-3/Amphotericin B

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