Document Detail

Cocaine use and preterm premature rupture of membranes: improvement in neonatal outcome.
MedLine Citation:
PMID:  12066089     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our aim was to determine whether cocaine use increases neonatal morbidity in patients with preterm premature rupture of membranes. STUDY DESIGN: We reviewed records of pregnancies that were complicated with preterm premature rupture of membranes between 24 weeks to 34 weeks of gestation. Clinical characteristics and neonatal outcomes of patients who had positive results for cocaine in the urine were compared with patients with negative test results. RESULTS: During the study period, 16.1% (85/528 patients) had a positive result in a urine screen for cocaine use. Patients who used cocaine were older and of higher gravidity and parity. When major neonatal morbidities were compared, there was improvement in morbidities that were linked to neonatal infection in patients with positive test results for cocaine, including pneumonia (3.5% vs 11.7%; P =.012) and sepsis (5.9% vs 14.7%; P =.016). Jointly, neonatal outcomes were significantly worse in the negative cocaine group (chi(2) = 5.143; P =.023). CONCLUSION: The association of preterm premature rupture of membranes with major neonatal morbidity was unexpectedly and significantly weaker in pregnancies complicated by cocaine use.
Jerrie S Refuerzo; Robert J Sokol; Sean C Blackwell; Stanley M Berry; James J Janisse; Yoram Sorokin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  186     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-14     Completed Date:  2002-07-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1150-4     Citation Subset:  AIM; IM    
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
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MeSH Terms
Bacterial Infections / etiology*,  physiopathology
Cocaine / adverse effects*,  pharmacology,  urine
Fetal Membranes, Premature Rupture / chemically induced*,  complications*,  physiopathology
Infant, Newborn
Infant, Newborn, Diseases / physiopathology*
Pneumonia / etiology*,  physiopathology
Pregnancy Outcome*
Reg. No./Substance:

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