Document Detail


Cocaine use in an urban medical population and the development of angiographically significant coronary artery disease.
MedLine Citation:
PMID:  16849877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cocaine is a common drug of abuse in the United States. Although long-term cocaine use has been associated with premature coronary artery disease (CAD), the relationship between cocaine use and the presence of angiographically significant CAD (> or =70%) is not clear. A retrospective analysis of all patients who had undergone cardiac catheterization at an urban medical center over a 1-year period was performed. Five hundred twelve patients were enrolled in the study; 84 (16.4%) had evidence of cocaine use, and 111 (21.7%) were admitted with a myocardial infarction. At the time of cardiac catheterization, 31 (36.9%) cocaine-positive patients had > or =70% stenosis in at least one epicardial vessel, compared with 200 (46.7%) cocaine-negative patients (p = 0.09). Although a trend toward an association was noted on unadjusted analysis, after adjusting for CAD risk factors, cocaine use was not associated with angiographically significant CAD (odds ratio, 0.9; 95% confidence interval, 0.55-1.5; p = 0.7).
Authors:
Amar D Patel; Srikanth Sola; Patrick Caneer; Faiz A Cheema; Divya Gupta; Tarek Helmy; Bobby V Khan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Preventive cardiology     Volume:  9     ISSN:  1520-037X     ISO Abbreviation:  Prev Cardiol     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-10-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9813731     Medline TA:  Prev Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  144-7     Citation Subset:  IM    
Affiliation:
Emory University School of Medicine, Division of Cardiology, Atlanta, GA 30303, USA.
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MeSH Terms
Descriptor/Qualifier:
Cocaine / contraindications*
Coronary Angiography / methods*
Coronary Artery Disease / epidemiology,  etiology,  radiography*
Female
Georgia / epidemiology
Heart Catheterization / methods
Humans
Male
Middle Aged
Narcotics / contraindications*
Retrospective Studies
Risk Factors
Urban Population
Chemical
Reg. No./Substance:
0/Narcotics; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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