Document Detail

Cocaine self-administration under conditions of restricted and unrestricted food access.
MedLine Citation:
PMID:  10609967     Owner:  NLM     Status:  MEDLINE    
Four rhesus monkeys (Macaca mulatta), maintained at reduced body weight and restricted food availability, had access to a 0.8-mg/ml cocaine solution and vehicle under a concurrent fixed-ratio (FR) 8 schedule. Over days, the cocaine concentration was reduced (0.57, 0.4, 0.2, 0.1, 0.05, 0.025) and then returned, gradually over days, to 0.8 mg/ml. The ratio value was then varied (to 16, 32, 64, 128, and 8). Food access was unrestricted, and the ratio and the concentration manipulations were then repeated. During food restriction cocaine served as a reinforcer for all monkeys, whereas during free feeding cocaine functioned as a reinforcer for 3 of 4 monkeys; with these monkeys, the dose-response curve obtained under free feeding was shifted to the right of that obtained under food restriction. There were no differences in FR response curves obtained during food restriction and unrestricted feeding. These data suggest that food restriction increases cocaine's reinforcing effects and that the higher the cocaine dose, the greater are the reinforcing effects. A demand curve analysis was completed, and data are discussed in terms of microeconomic principles.
M J Macenski; R A Meisch
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental and clinical psychopharmacology     Volume:  7     ISSN:  1064-1297     ISO Abbreviation:  Exp Clin Psychopharmacol     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-28     Completed Date:  2000-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9419066     Medline TA:  Exp Clin Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  324-37     Citation Subset:  IM    
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, USA.
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MeSH Terms
Body Weight / drug effects
Cocaine / administration & dosage,  pharmacology*
Dopamine Uptake Inhibitors / administration & dosage,  pharmacology*
Food Deprivation / physiology*
Macaca mulatta
Models, Economic
Models, Psychological
Reinforcement (Psychology)
Reinforcement Schedule
Self Administration
Grant Support
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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