| Cocaine is pharmacologically active in the nonhuman primate fetal brain. | |
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MedLine Citation:
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PMID: 20080687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cocaine use during pregnancy is deleterious to the newborn child, in part via its disruption of placental blood flow. However, the extent to which cocaine can affect the function of the fetal primate brain is still an unresolved question. Here we used PET and MRI and show that in third-trimester pregnant nonhuman primates, cocaine at doses typically used by drug abusers significantly increased brain glucose metabolism to the same extent in the mother as in the fetus (approximately 100%). Inasmuch as brain glucose metabolism is a sensitive marker of brain function, the current findings provide evidence that cocaine use by a pregnant mother will also affect the function of the fetal brain. We are also unique in showing that cocaine's effects in brain glucose metabolism differed in pregnant (increased) and nonpregnant (decreased) animals, which suggests that the psychoactive effects of cocaine are influenced by the state of pregnancy. Our findings have clinical implications because they imply that the adverse effects of prenatal cocaine exposure to the newborn child include not only cocaine's deleterious effects to the placental circulation, but also cocaine's direct pharmacological effect to the developing fetal brain. |
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Authors:
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Helene Benveniste; Joanna S Fowler; William D Rooney; Bruce A Scharf; W Walter Backus; Igor Izrailtyan; Gitte M Knudsen; Steen G Hasselbalch; Nora D Volkow |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-01-04 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-05 Completed Date: 2010-03-12 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 1582-7 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11794, USA. Benveniste@bnl.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects*, metabolism Cocaine / pharmacology* Female Fetus / drug effects* Glucose / metabolism Macaca radiata Magnetic Resonance Imaging Maternal Exposure* Maternal-Fetal Exchange / drug effects* Papio papio Positron-Emission Tomography Pregnancy |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 50-99-7/Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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