Document Detail


Cocaine and opiates use in pregnancy: detection of drugs in neonatal meconium and urine.
MedLine Citation:
PMID:  19796504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, the case of a newborn with symptoms of hyperexcitability was analyzed. After it was confirmed in the hospital that the mother had consumed drugs during pregnancy using an enzyme multiplied immunoassay technique, samples of the newborn's urine and meconium were sent to our laboratory to observe the evolution in the distribution of cocaine and opiates during the days following birth. For urine analysis, screening was done with an immunoassay technique, and the confirmation was done by gas chromatography-mass spectrometry (GC-MS) according to a published method. A GC-MS method for simultaneous analysis of cocaine, benzoylecgonine, codeine, morphine, and 6-acetylmorphine in meconium is described. GC-MS confirmation of urine and meconium results showed consumption of cocaine and codeine during pregnancy and also showed the levels of drugs gradually declined, totally disappearing by the third day.
Authors:
P López; A M Bermejo; M J Tabernero; P Cabarcos; I Alvarez; P Fernández
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of analytical toxicology     Volume:  33     ISSN:  0146-4760     ISO Abbreviation:  J Anal Toxicol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-02     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705085     Medline TA:  J Anal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351-5     Citation Subset:  IM    
Affiliation:
Institute of Legal Medicine, Forensic Toxicology Service, Faculty of Medicine, University of Santiago de Compostela, San Francisco, s/n, 15782, Santiago de Compostela, Spain. patricia.lopez@usc.es
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MeSH Terms
Descriptor/Qualifier:
Adult
Calibration
Cocaine / analysis*,  metabolism,  urine
Codeine / analysis,  metabolism,  urine
Female
Gas Chromatography-Mass Spectrometry
Heroin / analysis,  metabolism,  urine
Humans
Indicators and Reagents
Infant, Newborn
Meconium / chemistry*
Narcotics / analysis*,  metabolism,  urine
Pregnancy
Pregnancy Complications / diagnosis*,  metabolism,  urine
Reproducibility of Results
Substance Abuse Detection / methods*
Chemical
Reg. No./Substance:
0/Indicators and Reagents; 0/Narcotics; 50-36-2/Cocaine; 561-27-3/Heroin; 76-57-3/Codeine

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